Table 3.
Biochemical and metabolic measures of the 23 women who completed all arms of the study by insulin sensitivity sub-group (IR/IS) after 4 weeks of exposure to the indicated dose of RS. Mean (SD)
| IR (n = 14) | IS (n = 9) | |||||
|---|---|---|---|---|---|---|
| RS dose (g/day) | RS dose (g/day) | |||||
| 0 | 15 | 30 | 0 | 15 | 30 | |
| Glucose (mg/dL)* | 100.0 (12.3) | 98.3 (9.4) | 98.2 (13.0) | 87.9 (4.5) | 86.9 (6.6) | 91.6 (8.5) |
| Insulin (μIU/ml)** | 10.3 (4.6) | 9.8 (4.6) | 9.6 (6.9) | 4.0 (1.8) | 4.7 (2.0) | 4.6 (1.4) |
| SI [(×10-4 min-1 (μIU/ml)]*** | 3.80 (1.54) | 3.61 (1.60) | 4.68 (1.71) | 10.59 (5.77) | 8.73 (3.61) | 8.56 (2.95) |
| AIRg (μIU/mlx10 min) | 510.6 (378.9) | 438.1 (342.8) | 582.1 (524.4) | 380.0 (339.4) | 344.1 (257.3) | 403.3 (308.6) |
| DI | 2000.2 (2221.0) | 1444.7 (1197.6) | 2680.8 (2913.2) | 3342.9 (2507.4) | 2746.7 (2132.2) | 3470.9 (2992.3) |
| SG (min-1) | 0.020 (0.015) | 0.015 (0.008) | 0.021 (0.013) | 0.022 (0.007) | 0.027 (0.014) | 0.023 (0.011) |
| Total Chol. (mg/dL) | 187.6 (38.3) | 181.2 (24.4) | 190.4 (37.4) | 179.6 (32.2) | 182.4 (34.1) | 190.8 (41.9) |
| HDL-C (mg/dL) | 59.0 (18.0) | 58.8 (9.6) | 56.9 (14.3) | 61.9 (8.1) | 62.7 (8.9) | 62.9 (12.9) |
| TG (mg/dL) | 111.7 (47.9) | 111.8 (50.8) | 118.2 (59.1) | 83.7 (19.6) | 79.1 (27.0) | 96.1 (31.1) |
| Adiponectin (μg/mL) | 11.4 (5.7) | 11.4 (4.9) | 11.5 (5.4) | 16.2 (4.6) | 16.1 (4.3) | 17.7 (6.8) |
*P < 0.05, **P < 0.001 for IR vs IS at dose = 0 g/day
***P < 0.05 for dose effect within the IR sub-group. The 30 g/day dose differed from the 15 g/day dose (P < 0.05) and tended to differ from the 0 g/day dose (P = 0.068)
IR insulin resistant [SI value <7.8 ×10-4 min-1 / (μIU/ml)]
IS insulin sensitive [SI value ≥7.8 ×10-4 min-1 / (μIU/ml)]
S I insulin sensitivity by minimal model
AIRg acute insulin response to glucose
DI disposition index (dimensionless)
S G glucose effectiveness
TG triglycerides