Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1979 Aug;34(4):486–492. doi: 10.1136/thx.34.4.486

Tantalum inhalation and airway responses.

P Smith, F Stitik, J Smith, R Rosenthal, H Menkes
PMCID: PMC471102  PMID: 505345

Abstract

We studied the effects of tantalum inhalation bronchography on pulmonary function in 14 normal volunteers. Based on the radiographic type of deposition, the subjects were divided into three groups: (1) subjects who deposited tantalum mainly in the trachea, (2) subjects who deposited tantalum in segmental bronchi without radiographic evidence of bronchospasm, and (3) subjects who deposited tantalum in segmental bronchi with radiographic evidence of bronchospasm. Unlike the first two groups, the third group developed a significant but small decrease in the FEV. Airway reactivity as assessed by methacholine challenge did not explain the difference in response to tantalum in the third group. There were no consistent changes in total lung capacity, residual volume, or closing volume in any of the groups. Even though there were falls in FEV and specific conductance in individuals in groups 2 and 3, these changes did not pose any significant clinical risk.

Full text

PDF
486

Images in this article

487Image
on p.487
488Image
on p.488
488Image
on p.488
488Image
on p.488
488Image
on p.488

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anthonisen N. R., Danson J., Robertson P. C., Ross W. R. Airway closure as a function of age. Respir Physiol. 1969 Dec;8(1):58–65. doi: 10.1016/0034-5687(69)90044-9. [DOI] [PubMed] [Google Scholar]
  2. CHRISTOFORIDIS A. J., NELSON S. W., TOMASHEFSKI J. F. Effects of bronchography on pulmonary function. Am Rev Respir Dis. 1962 Jan;85:127–129. doi: 10.1164/arrd.1962.85.1.127. [DOI] [PubMed] [Google Scholar]
  3. DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DUBOIS A. B., DAUTREBANDE L. Acute effects of breathing inert dust particles and of carbachol aerosol on the mechanical characteristics of the lungs in man; changes in response after inhaling sympathomimetic aerosols. J Clin Invest. 1958 Dec;37(12):1746–1755. doi: 10.1172/JCI103767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dain D. S., Boushey H. A., Gold W. M. Inhibition of respiratory reflexes by local anesthetic aerosols in dogs and rabbits. J Appl Physiol. 1975 Jun;38(6):1045–1050. doi: 10.1152/jappl.1975.38.6.1045. [DOI] [PubMed] [Google Scholar]
  7. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  8. Fish J. E., Rosenthal R. R., Batra G., Menkes H., Summer W., Permutt S., Norman P. Airway responses to methacholine in allergic and nonallergic subjects. Am Rev Respir Dis. 1976 May;113(5):579–586. doi: 10.1164/arrd.1976.113.5.579. [DOI] [PubMed] [Google Scholar]
  9. Gamsu G., Weintraub R. M., Nadel J. A. Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method. Am Rev Respir Dis. 1973 Feb;107(2):214–224. doi: 10.1164/arrd.1973.107.2.214. [DOI] [PubMed] [Google Scholar]
  10. Loehning R. W., Waltemath C. L., Bergman N. A. Lidocaine and increased respiratory resistance produced by ultrasonic aerosols. Anesthesiology. 1976 Apr;44(4):306–310. doi: 10.1097/00000542-197604000-00008. [DOI] [PubMed] [Google Scholar]
  11. McFadden E. R., Jr, Kiser R., DeGroot W. J. Acute bronchial asthma. Relations between clinical and physiologic manifestations. N Engl J Med. 1973 Feb 1;288(5):221–225. doi: 10.1056/NEJM197302012880501. [DOI] [PubMed] [Google Scholar]
  12. Miller W. C., Awe R. Effect of nebulized lidocaine on reactive airways. Am Rev Respir Dis. 1975 Jun;111(6):739–741. doi: 10.1164/arrd.1975.111.6.739. [DOI] [PubMed] [Google Scholar]
  13. NADEL J. A., COMROE J. H., Jr Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul;16:713–716. doi: 10.1152/jappl.1961.16.4.713. [DOI] [PubMed] [Google Scholar]
  14. Nadel J. A., Wolfe W. G., Graf P. D. Powdered tantalum as a medium for bronchography in canine and human lungs. Invest Radiol. 1968 Jul-Aug;3(4):229–238. doi: 10.1097/00004424-196807000-00001. [DOI] [PubMed] [Google Scholar]
  15. Nadel J. A., Wolfe W. G., Graf P. D., Youker J. E., Zamel N., Austin J. H., Hinchcliffe W. A., Greenspan R. H., Wright R. R. Powdered tantalum. N Engl J Med. 1970 Aug 6;283(6):281–286. doi: 10.1056/NEJM197008062830603. [DOI] [PubMed] [Google Scholar]
  16. PARKER C. D., BILBO R. E., REED C. E. METHACHOLINE AEROSOL AS TEST FOR BRONCHIAL ASTHMA. Arch Intern Med. 1965 Apr;115:452–458. doi: 10.1001/archinte.1965.03860160078013. [DOI] [PubMed] [Google Scholar]
  17. Sellick H., Widdicombe J. G. Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol. J Appl Physiol. 1971 Jul;31(1):15–19. doi: 10.1152/jappl.1971.31.1.15. [DOI] [PubMed] [Google Scholar]
  18. Smith J. C., Stitik F. P., Swift D. L. Airway visualization by tantalum inhalation bronchography. Am Rev Respir Dis. 1976 Apr;113(4):515–529. doi: 10.1164/arrd.1976.113.4.515. [DOI] [PubMed] [Google Scholar]
  19. Stitik F. P., Proctor D. F. Tracheography with the experimental contrast agent tantalum. Ann Otol Rhinol Laryngol. 1973 Nov-Dec;82(6):838–843. doi: 10.1177/000348947308200616. [DOI] [PubMed] [Google Scholar]
  20. Stitik F. P., Proctor D. R. Delayed clearance of tantalum by radiologically occult cancer. Ann Otol Rhinol Laryngol. 1975 Sep-Oct;84(5 Pt 1):589–595. doi: 10.1177/000348947508400505. [DOI] [PubMed] [Google Scholar]
  21. TIFFENEAU R. Evaluation du degré de l'asthme par une épreuve pharmacodynamique; la mesure de l'excitabilité acétylcholinique du poumon. Bull Mem Soc Med Hop Paris. 1955;56(6):582–602. [PubMed] [Google Scholar]
  22. WIDDICOMBE J. G., KENT D. C., NADEL J. A. Mechanism of bronchoconstriction during inhalation of dust. J Appl Physiol. 1962 Jul;17:613–616. doi: 10.1152/jappl.1962.17.4.613. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES