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. 2016 Jan 13;17:50. doi: 10.1186/s12864-016-2383-1

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© Kučerová et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Altered gene expression in AKH, insulin/IGF- and TOR-signaling pathways in diapausing flies. The scheme displays a generalized assembly of relevant genes (regardless tissue-specificity) in the three signal pathways. Transcript levels (logarithmic fold change, LogFC) are given in red for upregulated, blue for downregulated and black for no significant change (ns; LogFC close to 0). The acronyms are listed in Additional file 6: Table S3 where also references and details of gene/protein functions are given. The AKH signaling is generally upregulated and the expression of the target gene tobi increased (X depicts an unidentified transcription factor). The Insulin/IGF signaling is generally downregulated and as a result several of the FOXO-regulated target genes are upregulated. The TOR-signaling is also downregulated, together with a number of its target genes. The AKH signaling scheme was compiled after [68, 171], the insulin/IGF signaling based on elements from [29, 36] and TOR signaling assembled after [35, 57]