Table 2.
Hormonal and monoamine signaling components affected by diapause
| Gene transcript | Role (main enrichmenta) | CG number | Log FC |
|---|---|---|---|
| Monoamine signaling | |||
| 5-HT2A (serotonin receptor 2) | Serotonin signaling (salivary gland, eye) | CG1056 | 2.2 |
| SerT (serotonin transporter) | Serotonin signaling (CNS, eye) | CG4545 | 1.4 |
| Ddc (Dopa decarboxylase) +2.82 CG10697 | Dopamine biosynthesis (CNS) | CG10697 | 2.8 |
| DAT (Dopamine transporter) +1.7 CG8380 + 1.35 CG3856 | Dopamine storage (CNS) | CG8380 | 1.7 |
| DopR2 (Dopamine receptor 2) +1.15 CG18741 | Dopamine signaling (CNS) | CG18741 | 1.1 |
| DopEcdR (Dopamine/Ecd receptor) +2.87 CG18314 | Dopamine ecdysone signaling (CNS) | CG18314 | 2.9 |
| Dat (Dopamine N acetyltransferase) +1.35 CG3318 | Dopamine inactivation (CNS, gut) | CG3318 | 1.4 |
| Tdc1 (Tyrosine decarboxylase 1) +1.56 CG30445 | Octopamine/tyramine biosynt. (gut) | CG30445 | 1.6 |
| Oamb (octopamine receptor) | Octopamine (OA) signaling (CNS) | CG3856 | 1.4 |
| Oct-TyrR (OA-Tyramine receptor) +1.84 CG7485 | Octopamine/tyramine signal. (CNS) | CG7485 | 1.8 |
| Ecdysone signaling | |||
| Spo (Spook) Cytochrome P450 | Ecdysone (Ecd) biosynthesis (ovary) | CG10594 | −1.6 |
| Eo (ecdysone oxidase) +2.44 CG9504 | Ecd metabolism (renal tubules; RT) | CG9504 | 2.4 |
| Usp (ultraspiracle) | Ecd receptor partner (ovary) | CG4380 | −1.3 |
| Cyp18a1 Cytochrome P450b | Ecd inducible (fat body, spermatheca) | CG6816 | 1.6 |
| Eip63F1 (Ecd induced protein 63 F1)c | Ecd inducible protein (CNS, gut, RT) | CG15855 | 2.0 |
| Eip75B (Ecd induced protein 75B)b + 1.1 CG8127) | Ecd inducible protein (ubiq.) | CG8127 | 1.1 |
| Eip74EF (Ecd induced prot. 74EF) +1.67 CG32180 | Ecd inducible proteind (brain, crop) | CG32180 | 1.7 |
| Ftz-f1 (ftz transcription factor 1) | Ecd and JHe inducible gene (ovary) | CG4059 | −1.9 |
| ImpL3 (ecd inducible gene L3) | Ecd inducible gene (midgut) | CG10160 | 2.4 |
| Br (Broad) | DNA-binding, Ecd response (CNS) | CG11491 | −1.5 |
| ecd (ecdysoneless) | Ecd biosynthesis ? (CNS, ovary) | CG5714 | −1.1 |
| Juvenile hormone signaling | |||
| Jhamt (JH acid methyltransferase) | JH biosynthesis (brain) | CG17330 | 1.8 |
| Jheh1 (JH epoxide hydrolase 1) | JH catabolic process (fat body, gut) | CG15101 | 1.3 |
| Jeheh3 (JH epoxide hydrolase 3) | JH catabolic process (gut) | CG15106 | 1.2 |
| Jhedup (JH esterase duplication) | Carboxylesterase activity (head) | CG8424 | 3.2 |
| Jhi1 (JH-inducible protein 1) | endoribonuclease activity (ubiq.) | CG3298 | −1.5 |
| jhi26 (JH-inducible protein 26) | Protein kinase-like (renal tubules) | CG3767 | 2.9 |
Notes: These transcripts are significantly affected more than two-fold (>LogFC 1)
aAdult expression (according to FlyAtlas)
bRead-out for increased ecdysone or 20-hydroxy ecdysone signaling during development [129, 130]
cEF-Hand 1, calcium-binding site
dmay be involved in autophagy
eJH, juvenile hormone