Table 3.
Genes shared between 3 weeks diapause and aging in Drosophila
| Symbol | Gene name | 3wD (logFC) | Longevity effect |
|---|---|---|---|
| ry | rosy | 2.4 | pro |
| Nlaz | Neural Lazarillo | 2.38 | pro |
| to | takeout | 2.21 | pro |
| Zw | Zwischenferment | 2.18 | pro |
| elav | embryonic lethal abnormal vision | 1.83 | pro |
| bsk | basket | 1.69 | pro |
| GstS1 | Glutathione S transferase S1 | 1.68 | pro |
| Nf1 | Neurofibromin 1 | 1.63 | pro |
| CG1623 | hebe | 1.54 | pro |
| Mlp84B | Muscle LIM protein at 84B | 1.45 | pro |
| CG11546 | kermit | 1.43 | pro |
| CG8846 | Thor | 1.3 | pro |
| Ilp6 | Insulin-like peptide 6 | 1.17 | pro |
| cher | cheerio | 1.13 | pro |
| rut | rutabaga | 1.01 | pro |
| srl | spargel | −1.06 | pro |
| bam | bag of marbles | −1.18 | pro |
| Daxx | Daxx-like protein | −1.4 | pro |
| POSH | Plenty of SH3s | −1.42 | pro |
| CG5671 | Pten | −1.71 | pro |
| Mt2 | Methyltransferase 2 | −2.14 | pro |
| Hsp26 | Heat shock protein 26 | −2.89 | pro |
| Hsp27 | Heat shock protein 27 | −3.15 | pro |
| CG6284 | Sirt6 | −3.41 | pro |
| a-Man-Ia | alpha Mannosidase I | 2.01 | anti |
| Ilp2 | Insulin-like peptide 2 | 1.9 | anti |
| E(z) | Enhancer of zeste | −1 | anti |
| snz | snazarus | −1.2 | anti |
| Edem1 | ER degradation enhancer mannosidase alpha-like 1 | −1.35 | anti |
| kuk | kugelkern | −1.36 | anti |
| LBR | Lamin B receptor | −1.91 | anti |
| CG6824 | ovo | −1.98 | anti |
| esc | extra sexcombs | −2.44 | anti |
| Hsp22 | Hsp22 | −1.13 | both |
Notes: During diapause 34 genes out of 136 hits for aging genes in GenAge database were found to be significantly regulated (q < 0.05, |logFC| > 1). Comparison with the GenAge database [133, 134] http://genomics.senescence.info/genes/