Fig. 3.

a Stiffness vs. lung injury. Distributions of the median entry times (ETs) measured after 1-h incubation of THP-1 cells with the sera of healthy donors (control; n = 5), patients with acute cardiogenic pulmonary edema (ACPE; n = 6), patients with mild acute respiratory distress syndrome (ARDS; n = 9, among whom 5 had septic shock [SS]), and patients with moderate to severe ARDS (n = 13, among whom 10 had septic shock). b Stiffness vs. SS. Distributions of the median ETs measured after 1-h incubation of THP-1 cells with the sera of healthy subjects (n = 5), patients with ACPE (n = 6), patients with ARDS but without septic shock (n = 7), and patients with both ARDS and septic shock (n = 15). The number of tested cells per patient was 50. Box plots represent the median (black bar inside box), interquartile range (box), and minimum and maximum values (whiskers). *p < 0.05; **p < 0.0025; ***p < 0.0001 (Mann-Whitney U test)