Fig. 6.
The effect of SZV558 on the behavior in the chronic MPTPp induced PD in mice. Adult mice were treated with vehicle plus probenecid, or MPTP (25 mg/kg i.p.) plus probenecid (100 mg/kg i.p.), administered 30 min before each MPTPp, twice a week for 5 weeks, alone, or in the presence of the SZV558 (1 mg/kg i.p.) or rasagiline (1 mg/kg i.p.) administered 18 h before each MPTPp administration. a-b Beam-walking test. To evaluate the number of steps (a) and the total errors (b), the mice were videotaped for a total of five trials, 2 days after the 10th MPTPp administration. The number of steps and the number of errors were calculated across all five trials and averaged for each group. * P < 0.05 compared with vehicle, # P < 0.05 compared with MPTPp. c Inverted grid test. To assess skilled forepaw use, the latency time of falling down was measured 2 days after the 10th MPTPp administration. d Olfactory test. To evaluate the olfactory deficit, the retrieval time of a buried smelling pellet was measured 3 days after the 10th MPTPp administration. * P < 0.05 compared with MPTPp. Values are expressed as mean ± SEM. Data were statistically compared with one-way ANOVA, followed by the Newman-Keuls post hoc test. N: 4–7/group