TABLE 1.

Baseline titers and fold changes for IgA and IgG response to LPS, LTB, and CFA/I in serum ALS, fecal, and saliva samples^a

Antigen and antibody	Baseline titer			Fold increase of titer on day:
				7		10		28		84
	N	RC	RC/N	N	RC	N	RC	N	RC	N	RC
LPS
Serum IgA	13.76	58.81	4.28**	18.91**	1.40	59.63**	1.61	11.46**	0.94	3.92*	0.65
Serum IgG	146.7	969.6	6.61**	2.96**	1.02	7.85**	1.05	5.10**	0.96	6.35**	0.87
ALS IgA	0.37	0.26	0.70	1,093**	18.23	38.66**	5.24**	2.17*	1.81	1.37	1.17
Fecal IgA	20.41	425.9	20.9*	ND	ND	86.63*	4.42	21.34**	3.59	6.11	1.53
Parotid IgA	697.6	659.5	0.95	1.99	1.15	3.02	0.95	1.31	1.46	0.77	1.17
Sublingual IgA	794.5	670.4	0.76	1.5	1.16	4.53	2.0	1.9	2.13	1.73	1.86
LTB
Serum IgA	237.3	399.4	1.68*	1.66*	1.22	2.51**	1.40	2.10**	1.10	1.27	1.14
Serum IgG	632.5	758.2	1.20	1.15	1.02	1.67	1.04	2.32**	0.98	0.89	0.83
ALS IgA	0.41	0.19	0.46	14.28**	10.20**	5.37**	3.65	1.88**	1.68	0.06	1.30
Fecal IgA	21.03	73.97	3.52	ND	ND	2.37	2.95	3.63	2.43	3.74	1.12
Parotid IgA	4,402	6,332	1.44	0.96	0.32	1.62	1.06	0.69	1.24	0.49	0.25
Sublingual IgA	7,628	5,275	0.69	0.93	1.48	0.95	1.94	1.0	1.65	0.40	1.40
CFA/I
Serum IgA	168.4	248.1	1.47	1.17	1.90	1.47	2.38*	2.08**	1.30	2.02*	1.21
Serum IgG	366.5	251.9	0.69	1.10	1.90	1.37	2.38*	1.66	1.30	0.94	1.21
ALS IgA	0.36	0.78	2.17	4.14**	4.93**	1.81	2.11	2.17**	1.27	0.82	0.29
Fecal IgA	12.43	9.30	0.75	ND	ND	0.42	1.61	0.55	0.66	1.94	0.94

^aN, naive subjects; RC, rechallenged subjects; RC/N, fold increase of baseline titers in rechallenged compared to naive subjects; ND, not done. All the fold increases are compared to the baseline (the day before challenge in naive subjects and the day before rechallenge in rechallenged subjects). *, P < 0.05; **, P < 0.005.