Fig. 5.

CETP expression does not affect glucose tolerance, insulin sensitivity and secretion in obese mice. Glucose tolerance test performed in NTg and CETP female mice treated with high fat diet from 2 to 5 months of age, after 12 hs of fasting, n = 5–7 per group (a). lntraperitoneal (ip) insulin-tolerance test (ITT) was performed after 3 h fasting, n = 6–8 (b). Freshly isolated islets from NTg mice fed with chow diet (black columns), and NTg (white columns) and CETP (gray columns) mice fed with high fat diet were incubated in the presence of 2.8 mM glucose, 2.8 mM glucose plus KCl (40 mM), 11 mM glucose or 22.2 mM glucose, as described in Fig. 2, n = 2–4 female mice in two independent experiments (c). Values are expressed as mean ± S.E. Student’s t test: non-significant