TABLE 3.
Examples of bioactive molecules produced by Actinobacteria genera and their activities
| Type of compound and producing species | Bioactive agent(s) | Source or reference |
|---|---|---|
| Antibacterial agent producers | ||
| Verrucosispora spp. | Abyssomycin | 603 |
| Streptomyces anulatus | Actinomycins | 409 |
| Streptomyces canus | Amphomycin | 604 |
| Micromonospora spp. | Anthracyclin | 605 |
| Streptomyces cattley | Antibiotics and fluorometabolites | 606 |
| Streptomyces canus | Aspartocins | 607 |
| Streptomyces avermitilis | Avermectin | 608 |
| Streptomyces venezuelae | Chloramphenicol | 609 |
| Micromonospora spp. | Clostomicins | 609 |
| Streptomyces griseus | Cycloheximide | 620 |
| Streptomyces orchidaceus | Cycloserine | 610 |
| Streptomyces roseosporus | Daptomycin | 611 |
| Saccharopolyspora erythraea | Erythromycin (Ilotycin) | 612 |
| Micromonospora purpurea | Gentamicin | 613 |
| Streptomyces hygroscopicus | Hygromycin | 614 |
| Streptomyces kanamyceticus | Kanamycin | 615 |
| Streptomyces kitasoensis | Leucomycin | 616 |
| Streptomyces lincolnensis | Lincomycin | 617 |
| Marinispora spp. | Marinomycin | 618 |
| Streptomyces fradiae | Neomycins | 619 |
| Micromonospora spp. | Netamicin | 80 |
| Streptomyces niveus | Novobiocin | 620 |
| Streptomyces antibioticus | Oleandomycin | 621 |
| Streptomyces rimosus | Oxytetracycline | 622 |
| Streptomyces spp. | Pristinamycin | 623 |
| Streptomyces lindensis | Retamycin | 624 |
| Streptomyces mediterranei | Rifamycin | 625 |
| Nocardia lurida | Ristocetin | 621 |
| Streptomyces ambofaciens | Spiramycin | 626 |
| Streptomyces virginiae | Staphylomycin | 627 |
| Streptomyces endus | Stendomycin | 628 |
| Streptomyces lydicus | Streptolydigin | 629 |
| Streptomyces griseus | Streptomycin | 411 |
| Streptomyces lavendulae | Streptothricin | 410 |
| Streptomyces aureofaciens | Tetracycline | 630 |
| Micromonospora spp. | Thiocoraline | 631 |
| Amycolatopsis orientalis | Vancomycin | 632 |
| Antifungal agent producers | ||
| Streptomyces anulatus | Actinomycins | 603 |
| Streptomyces nodosus | Amphotericin B | 633 |
| Streptomyces griseochromogenes | Blasticidin | 634 |
| Streptomyces griseus | Candicidin | 635 |
| Streptomyces spp. | Carboxamycin | 636 |
| Streptomyces venezuelae | Chloramphenicol | 637 |
| Streptomyces padanus | Fungichromin | 638 |
| Streptomyces galbus | Galbonolides | 675 |
| Streptomyces violaceusniger YCED-9 | Guanidylfungin | 564 |
| Streptomyces venezuelae | Jadomycin | 639 |
| Streptomyces kasugaensis | Kasugamycin | 452 |
| Streptomyces spp. | Kitamycin | 640 |
| Streptomyces natalensis | Natamycin | 641 |
| Streptomyces tendae | Nikkomycin | 642 |
| Streptomyces diastatochromogenes | Oligomycin | 643 |
| Streptomyces humidus | Phenylacetate | 644 |
| Streptomyces cacaoi | Polyoxin B | 453 |
| Streptomyces canus | Resistomycin | 645 |
| Streptomyces lavendulae | Streptothricin | 410 |
| Streptomyces canus | Tetracenomycin | 645 |
| Nocardia transvalensis | Transvalencin | 646 |
| Streptomyces hygroscopicus | Validamycin | 647 |
| Bioherbicide/biopesticide producers | ||
| Actinomadura spp. | 2,4-Dihydro-4-(β-d-ribofuranosyl)-1, 2, 4 (3H)-triazol-3-one (herbicide) | 648 |
| Streptomyces hygroscopicus | Herbimycin | 649 |
| Streptomyces avermitilis | Ivermectin (derivative of avermectin) | 650 |
| Streptomyces prasinus | Prasinons | 651 |
| Saccharopolyspora spinosa | Spinosad (neurotoxic insecticides) | 652 |
| Antiparasitic agent producers | ||
| Streptomyces avermitilis | Avermectins | 608 |
| Streptomyces coelicolor | Prodiginine | 653 |
| Streptomyces bottropensis | Trioxacarcin | 654 |
| Antiviral agent producers | ||
| Streptomyces antibioticus | 9-β-d-Arabinofuranosyladénine | 655 |
| Streptomyces hygroscopicus | Hygromycin | 614 |
| Streptomyces spp. | Panosialins | 656 |
| Hypercholesterolemia agent producer | ||
| Streptomyces hygroscopicus | Rapamycin | 674 |
| Antitumor agent producers | ||
| Micromonospora spp. | Anthraquinones | 657 |
| Nocardia asteroides | Asterobactine | 658 |
| Streptomyces spp. | Borrelidine | 659 |
| Micromonospora spp. | Diazepinomicin | 660 |
| Actinomadura spp. | IB-00208 | 661 |
| Micromonospora spp. | LL-E33288 complex | 76 |
| Micromonospora spp. | Lomaiviticins | 76 |
| Micromonospora spp. | Lupinacidins | 657 |
| Thermoactinomyces spp. | Mechercharmycin | 662 |
| Marinospora spp. | Marinomycin | 618 |
| Salinispora tropica | Salinosporamide | 621 |
| Streptomyces peucetius | Doxorubicin (adriamycin) | 664 |
| Streptomyces peucetius | Daunorubicin (daunomycin) | 665 |
| Micromonospora spp. | Tetrocarcin | 76 |
| Micromonospora spp. | Thiocoraline | 666 |
| Immunostimulatory agent producers | ||
| Nocardia rubra | Rubratin | 667 |
| Streptomyces olivoreticuli | Bestatin | 668 |
| Kitasatospora kifunense | FR-900494 | 669 |
| Immunosuppressive agent producers | ||
| Nocardia brasiliensis | Brasilicardin | 670 |
| Streptomyces filipinensis | Hygromycin | 671 |
| Streptomyces filipinensis | Pentalenolactone | 671 |
| Therapeutic enzyme (antitumor) producers | ||
| Streptomyces spp. | l-Asparaginase | 672 |
| Streptomyces olivochromogenes | l-Glutaminase | 673 |