Table 1.
Summary of the 4 cases of HSTCL.
| Case no. | Age (y)/Sex | Country | Immuno-deficiency | Clinical stage (cs) | B symptoms | Hepato-megaly | Spleno-megaly | IPI |
|---|---|---|---|---|---|---|---|---|
| 1 | 74/F | Japan | − | ⅣB | + | + | + | High |
| 2 | 64/M | Japan | − | ⅣB | + | + | + | High |
| 3 | 59/M | Japan | − | ⅣB | + | + | + | High |
| 4 | 23/M | Japan | − | ⅣB | + | + | + | High-int |
| Peripheral blood |
Histological detection of tumor cells | ||||
|---|---|---|---|---|---|
| WBC (109/L) | Hgb (g/dL) | Platelet (109/L) | Elevated LD (U/L) | anti-HTLV1 | |
| 5.9 | 7.2 | 109 | 449 | − | Liver, BM |
| 1.8 | 12.2 | 54 | 390 | − | Liver, BM |
| 0.3 | 5.2 | 25 | 577 | − | BM |
| 7.1 | 9.1 | 95 | 522 | − | BM |
| Immunohistochemical staining of tumor cells |
Outcome/follow-up (months) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CD2 | CD3 | CD4 | CD5 | CD7 | CD8 | CD56 | TIA-1 | Granzyme B | EBER | TCR | |
| + | + | − | − | + | − | + | + | − | − | γδ | Alive/12M |
| + | + | − | − | + | + | + | + | + | − | γδ | Dead/37M |
| NS | + | − | − | NS | − | NS | NS | NS | − | NS | Dead/11M |
| + | + | − | − | + | − | − | + | − | − | γδ | Dead/19M |
PS, performance status; IPI, International Prognostic Index; WBC, leukocyte count; Hgb, hemoglobin level; LD, lactate dehydrogenase level; BM, bone marrow; EBER, EB virus-encoded small RNAs; TCR, T-cell receptor; PSL, Prednisolone; NS, not specified