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. 2016 Jan 13;6:320. doi: 10.3389/fphar.2015.00320

FIGURE 1.

FIGURE 1

Effects of celastrol on the general health and survival of mice treated with azoxymethane (AOM) and dextran sodium sulfate (DSS). (A) Experimental protocol for ulcerative colitis-related colorectal cancer (UC-CRC) model and treatment. The details were described in the section “Materials and Methods.” (B) Effect of celastrol (2 mg/kg) on body weight of mice. Body weight of each mouse was measured once per week. (C) Effect of celastrol (2 mg/kg) on survival ratio of mice. Survival status of each mouse was recorded every week. Fifteen mice in the control group, 30 mice in model group, and 20 mice in celastrol group. (D) Effect of celastrol (2 mg/kg) on colon weight and colon length. At the end of experiment, colon tissues were removed and the weight and length were measured. Data are presented as mean ± SD. ∗∗p < 0.01 vs. the control group; #p < 0.05 and ##p < 0.01 vs. the AOM/DSS model group.