Table 3. Cox proportional hazards regression and logistic regression analysis of association of RC calculated from 2 serial PSAVs in 12 and 24-month windows from beginning of AS with biopsy reclassification during full patient followup or immediate next year in Johns Hopkins AS Program from 1995 to 2012.

	Full Followup		Next Yr
RC vs 0	HR (95% CI)*	p Value	HR (95% CI)*	p Value
12-Mo window (318 pts)
Any criteria:
1	1.32 (0.82–2.15)	0.256	0.99 (0.42–2.34)	0.982
2	1.27 (0.65–2.48)	0.483	2.27 (0.85–6.06)	0.101
Gleason score reclassification:
1	1.60 (0.77–3.32)	0.209	0.48 (0.12–2.00)	0.313
2	2.29 (0.85–6.14)	0.101	2.09 (0.49–8.87)	0.32
24-Mo window (168 pts)
Any criteria:
1	1.10 (0.55–2.18)	0.792	1.30 (0.36–4.74)	0.689
2	1.90 (0.61–5.90)	0.266	4.99 (1.08–23.00)	0.039
Gleason score reclassification:
1	0.42 (0.14–1.28)	0.127	1.03 (0.13–8.04)	0.975
2	1.22 (0.21–7.16)	0.822	7.80 (0.54–113.25)	0.132

^*Adjusted for age at diagnosis, race, PSAD at diagnosis, overall PSAV during followup and cancer on first surveillance biopsy.