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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Sep 14;54(45):13390–13392. doi: 10.1002/anie.201506884

Table 1.

Initial TADDOL ligand screen.[a]

graphic file with name nihms-741699-f0002.jpg
[a]

Conditions: 1.0 equiv 1a, 1.8 equiv. 2-bromonaphthalene, 1.8 equiv. NaOtBu, 2 mol % Pd2(dba)3, 6 mol % chiral ligand, toluene (0.2 M), 90 °C, 12–14 h. Reactions were conducted on a 0.10 mmol scale. In all cases regioisomer 3 was formed in ca. 10% yield.