TABLE 5.

Effects of Days of Cocaine Use and Other Factors on Endothelin-1 Levels (Square-Root Transformed): Generalized Estimating Equation Analysis (N = 57)

	Bivariate Model*			Multivariate Model
Factor	Regression Coefficient	SE	P	Regression Coefficient	SE	P
Family history of heart attack	0.0283	0.0572	0.62	0.0251	0.0567	0.66
hsCRP >2.0, mg/dL	−0.0866	0.0431	0.045	−0.0977	0.0492	0.047
Baseline ET-1 <1.0, pg/mL	−0.2741	0.0290	<0.0001	−0.2931	0.0391	<0.0001
Low 2013 ACC/AHA risk	−0.0148	0.0543	0.79	−0.0419	0.0645	0.52
Reduction in cocaine use in the 6 mos	−0.0006	0.0003	0.07	−0.0007	0.0003	0.021

^*Adjusted Tor baseline ET-1 <l.0pg/mL.

ET-1 endothelin-1; hsCRP, high-sensitivity C-reactive protein; Low 2013 ACC/AHA risk, cardiovascular risk defined by the 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk ≤7.5% (Goff et al, 2014); SE, standard error.