TABLE III.
Occupancy values (%) of each platinum atom at the Nδ and Nε binding sites of His-15. Occupancies were calculated using SHELX12 and the errors on the occupancies were calculated using the full matrix inversion in SHELXL.
| Nδ binding site | Nε binding site | |||||
|---|---|---|---|---|---|---|
| Pt 1 | Pt 2 | Pt 1 | Pt 2 | Pt 3 | Pt 4 | |
| Cisplatin HEWL crystal at 150 K | 22 +/− 5 | 13 +/− 12 | 7 +/− 9 | 60 +/− 2 | 22 +/− 9 | 25 +/− 8 |
| Cisplatin HEWL crystal at 200 K | 29 +/− 10 | 14 +/− 9 | 16 +/− 12 | 44 +/− 13 | ||
| Cisplatin HEWL crystal at RT | 36 +/− 2 | 29 +/− 2 | 33 +/− 2 | |||
| Carboplatin HEWL crystal at 200 K | 20 +/− 5 | 32 +/− 7 | 23 +/− 8 | |||