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Crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex in IL-1β induced SCF production and secretion. eIF4E, eukaryotic translation initiation factor 4E; HIF, hypoxia-inducible factor; mTOR, mammalian target of rapamycin; PDK, phosphatidylinositol (P-3-PI)-dependent kinase; PI-3K, phosphatidylinositol-3 kinase; SCF, stem cell factor; S6K1, ribosomal protein S6 kinase beta-1; TSC, tuberous sclerosis complex.
