Table 3. Immune responses elicited by CYD-TDV and YF-17D vaccines.
| Immune responses types | CYD-TDV | YF-17D | References | ||
|---|---|---|---|---|---|
| Innate immunity | NK | IFN-γ+ | ND | ↑ | 41 |
| IL-4+ | ND | ↓ | 41 | ||
| CD56+CD69+ | ND | ↑ | 40 | ||
| CD56+CD16+ | ND | ↑ | 40 | ||
| mDC | CD80+ | ↑ | ↑ | 34,107 | |
| CD83+ | ↑ | — | 33,34,107 | ||
| CD86+ | ↑ | ↑ | 32,33,34,107 | ||
| IL-10+ | — | ↑ | 34,107 | ||
| IL-1β | — | ↑ | 38,107 | ||
| pDC | ND | ↑ | 34,38 | ||
| Monocyte | TNF-α+ | ND | ↑ | 41,43,44 | |
| IL-10+ | ND | ↑ | 41,43 | ||
| Adaptive immunity | CD8+ T | IFN-γ+ | ↑ | ↑ | 26,45,49,50,108 |
| CD4+ T | IL-4+ | — | ↑ | 34,54,55,108 | |
| TNF-α+ | — | ↑ | 34,54,55,108 | ||
| IFN-γ+ | CYD-4 ↑ | ↑ | 34,54,55,108 | ||
| IL-2+ | — | ↑ | 34,54,55,108 | ||
| nAbs | IgM | ND | ↑ | 74,75 | |
| IgG | ND | ↑ | 59 | ||
| Viremia | ∼10% | ∼100% | 25,26,116,121 | ||
↑, Up-regulated; ↓, down-regulated; —, Non-significant changed
nAbs, neutralizing antibodies; ND, Not determined.