Skip to main content
. 2015 Dec 23;113(1):E16–E22. doi: 10.1073/pnas.1519273113

Fig. 2.

Fig. 2.

αCD38mAb targets MCL cells and induces cellular internalization. (A) αCD38 mAb binding to four MCL cell lines. Continuous line: αCD38. Dashed lines: isotype control. (B) αCD38 mAb binding to MCL cells (CD5+/CD19+) relative to non-MCL leukocytes present in blood samples from MCL patients. Each dot represents one sample (n = 5); horizontal bar represents mean (*P < 0.05; two-tailed Student’s t test for paired values). (C) αCD38 mAb internalization upon binding to Granta-519 cells. (Scale bar: 20 μm.) (D) In vivo binding of αCD38 mAb to different organs in representative MCL-bearing mouse. Indicated organs were extracted 2 h post αCD38 mAb injection, suspended, and analyzed by flow cytometry. αCD38 mAb can be found on most MCL cells (Granta-GFP cells) in the BM.