Table S3.
Electrophysiological properties of LOV2-PAH1–transduced primary neurons
| Cell parameter | LOV2-PAH1 dark | LOV2-PAH1 light |
| n | 21 | 21 |
| Maximum firing rate (Hz) | 18.57 ± 0.98* | 48.67 ± 4.86 |
| Current threshold (pA) | 152.4 ± 14.01 | 179.8 ± 11.52 |
| Membrane capacitance (pF) | 49.02 ± 4.56 | 50.05 ± 4.00 |
| Membrane resistance (MΩ) | 259.5 ± 23.32 | 210.4 ± 11.47 |
| Voltage threshold (mV) | −17.20 ± 2.31 | −18.31 ± 1.93 |
| AP amplitude (mV) | 49.51 ± 3.21 | 53.79 ± 2.37 |
| AHP (mV) | −21.58 ± 2.17 | −20.74 ± 1.59 |
| AP width 50% (ms) | 1.195 ± 0.061 | 1.171 ± 0.059 |
| Rising slope (V/s) | 22.71 ± 2.04 | 28.92 ± 2.66 |
| Repolarizing slope (V/s) | −9.490 ± 0.61 | −10.09 ± 0.57 |
Electrophysiological parameters describing the passive membrane properties and the shape of the first elicited action potential measured for neurons transduced with LOV2-PAH1 and kept under either dark or lit conditions for 24 h. The analysis refers to the experiments and data reported in Fig. 6.
*
P < 0.001; unpaired Student t test.