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Aging has unique effects on the circadian gene expression patterns of period genes (PER family) in both BA11 (A) and BA47 (B). Older people have disrupted PER1 circadian expression patterns (P = 0.027 in BA11; P = 0.0005 in BA47), together with a phase advance of PER2 expression from sunset to noon (P = 0.005 in BA11; P = 0.004 in BA47), whereas their PER3 expression remained intact.
