Table S1.
Cohort demographic and clinical information
| HU | Age | PMI | pH | RIN | Sex | Race | Cause | Manner | TOD |
| 510 | 63 | 12.4 | 6.5 | 7.5 | M | W | Gastrointestinal bleeding | Natural | −5.83 |
| 516 | 20 | 14 | 7.1 | 8.4 | M | B | Gunshot wound to chest | Homicide | 16.66 |
| 545 | 65 | 13.1 | 6.9 | 6.2 | M | B | Pancreatic carcinoma with pulmonary metastasis | Natural | 14.90 |
| 546 | 37 | 23.5 | 6.7 | 8.6 | F | W | ASCVD | Natural | 6.07 |
| 551 | 61 | 16.4 | 6.6 | 8.3 | M | W | Cardiac tamponade | Natural | 11.35 |
| 567 | 46 | 15 | 6.8 | 8.9 | F | W | Mitral valve prolapse | Natural | 14.11 |
| 568 | 60 | 9.5 | 6.9 | 8.7 | F | W | ASCVD | Natural | −5.47 |
| 575 | 55 | 11.3 | 6.8 | 9.6 | F | B | ASCVD | Natural | 15.78 |
| 585 | 26 | 16 | 6.7 | 8.3 | M | W | Trauma | Accidental | 15.60 |
| 604 | 39 | 19.3 | 7.1 | 8.6 | M | W | Hypoplastic coronary artery | Natural | 9.27 |
| 615 | 62 | 7.2 | 6.4 | 7.8 | M | W | Ruptured abdominal aortic aneurysm | Natural | −3.38 |
| 627 | 43 | 14.1 | 7.1 | 7 | F | B | Chronic obstructive pulmonary disease | Natural | 14.62 |
| 630 | 65 | 21.2 | 7 | 9 | M | W | ASCVD | Natural | 6.39 |
| 634 | 52 | 16.2 | 7 | 8.5 | M | W | ASCVD | Natural | 13.54 |
| 643 | 50 | 24 | 6.2 | 8 | M | W | ASCVD | Natural | 4.34 |
| 645 | 69 | 23 | 6.7 | 8 | M | W | ASCVD | Accidental | 4.91 |
| 681 | 51 | 11.6 | 7.2 | 8.9 | M | W | Hypertrophic cardiomyopathy | Natural | 16.00 |
| 688 | 55 | 21.5 | 7 | 7.2 | M | W | Hypertrophic cardiomyopathy | Natural | 7.61 |
| 694 | 38 | 20.7 | 7 | 7.7 | M | W | Subarachnoid hemorrhage | Natural | 8.95 |
| 700 | 42 | 26.1 | 7 | 8.7 | M | W | ASCVD | Natural | 3.64 |
| 704 | 70 | 20.6 | 7 | 8.7 | M | W | ASCVD | Natural | 10.56 |
| 727 | 19 | 7 | 7.4 | 9.2 | M | B | Multiple trauma | Accidental | −2.83 |
| 731 | 63 | 10.5 | 6.8 | 8.2 | F | W | ASCVD | Natural | −4.11 |
| 737 | 66 | 18.2 | 7.3 | 7.5 | M | W | ASCVD | Natural | 10.81 |
| 739 | 40 | 15.8 | 6.9 | 8.4 | M | W | ASCVD | Natural | 11.25 |
| 746 | 64 | 20.8 | 6.7 | 7.6 | F | B | Peritonitis | Natural | 7.90 |
| 784 | 58 | 5.5 | 7.1 | 9.1 | M | W | ASCVD | Natural | −2.70 |
| 794 | 52 | 20 | 6.8 | 8.4 | M | B | End-stage dilated cardiomyopathy | Natural | 6.68 |
| 795 | 68 | 11.8 | 6.8 | 8.2 | M | W | Ruptured abdominal aortic aneurysm | Natural | 15.13 |
| 806 | 57 | 24 | 6.9 | 7.8 | M | W | Pulmonary embolism | Natural | 4.31 |
| 812 | 55 | 23 | 6.7 | 8.5 | M | W | ASCVD | Natural | 4.37 |
| 818 | 67 | 24 | 7.1 | 8.4 | F | W | Anaphylactic reaction to cef0tan | Accidental | 5.35 |
| 825 | 59 | 16.9 | 7.1 | 7.8 | M | W | Cardiac tamponade | Natural | 12.60 |
| 838 | 58 | 16.5 | 7 | 8.5 | M | W | ASCVD | Natural | 12.43 |
| 839 | 74 | 5.3 | 7.1 | 8.9 | F | W | Massive BFT | Accidental | −1.15 |
| 840 | 41 | 15.4 | 6.8 | 9.1 | F | W | ASCVD | Natural | 13.97 |
| 841 | 70 | 22.3 | 7.2 | 7.2 | M | W | Hypertrophic cardiomyopathy | Natural | 7.69 |
| 855 | 62 | 11.5 | 6.7 | 8.4 | M | B | Hypertrophic cardiomyopathy | Natural | 17.28 |
| 857 | 48 | 16.6 | 6.7 | 8.9 | M | W | ASCVD | Natural | 10.13 |
| 866 | 66 | 12.2 | 7 | 8.5 | M | W | ASCVD | Natural | 15.24 |
| 869 | 51 | 6.5 | 7.2 | 8.9 | M | W | Severe ASCVD | Natural | −3.46 |
| 871 | 28 | 16.5 | 7.1 | 8.5 | M | W | Trauma (chest) | Accidental | 12.04 |
| 895 | 39 | 15.4 | 7.6 | 8.8 | M | W | ASCVD | Natural | 14.25 |
| 902 | 60 | 23.6 | 6.7 | 7.7 | M | W | ASCVD | Natural | 4.45 |
| 920 | 60 | 23 | 7.2 | 8.5 | M | W | ASCVD | Natural | 3.93 |
| 932 | 68 | 25.9 | 6.8 | 8.3 | M | W | Cardiac tamponade | Natural | 2.23 |
| 952 | 62 | 5.5 | 6.6 | 8.7 | M | W | ASCVD | Natural | 4.08 |
| 953 | 54 | 18.6 | 6.2 | 7.1 | M | W | Extensive BFT (head, torso, and limbs) | Accidental | 9.38 |
| 969 | 27 | 10.6 | 7 | 7.7 | M | W | Trauma to trunk and extremities | Accidental | −4.91 |
| 970 | 42 | 25.9 | 6.4 | 7.2 | M | W | ASCVD | Natural | 4.38 |
| 972 | 72 | 16.4 | 6.3 | 7.7 | M | W | Trauma (cervical/upper thoracic vertebra) | Accidental | 11.71 |
| 980 | 52 | 11 | 6.4 | 8.3 | M | W | ASCVD | Natural | −5.96 |
| 998 | 25 | 6.3 | 5.9 | 7.6 | M | W | Pulmonary thromboembolism | Natural | 2.24 |
| 1026 | 59 | 19.8 | 6.3 | 7.4 | M | W | ASCVD | Natural | 9.64 |
| 1030 | 96 | 13.2 | 6.3 | 6.8 | F | W | Fractured cervical spinal column | Accidental | 16.16 |
| 1031 | 53 | 23.2 | 6.8 | 8.9 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 6.71 |
| 1038 | 56 | 14.6 | 6.5 | 7 | M | W | Rupture of dissecting hematoma of aorta | Natural | 14.64 |
| 1047 | 43 | 13.8 | 6.6 | 9 | M | W | ASCVD | Natural | 15.15 |
| 1054 | 44 | 17.1 | 6.6 | 8.8 | F | W | ASCVD | Natural | 10.20 |
| 1065 | 85 | 20.2 | 6.3 | 7.1 | M | B | Pulmonary embolism | Accidental | 7.32 |
| 1067 | 49 | 6 | 6.6 | 8.2 | M | W | Hypertensive heart disease | Natural | −1.95 |
| 1083 | 20 | 19.9 | 6.6 | 8.8 | M | W | Trauma (head and trunk) | Accidental | 9.20 |
| 1091 | 58 | 16.5 | 6.6 | 8.1 | M | W | ASCVD | Natural | 6.67 |
| 1092 | 40 | 16.6 | 6.8 | 8 | F | B | Mitral valve prolapse | Natural | 11.81 |
| 1099 | 24 | 9.1 | 6.5 | 8.6 | F | W | Cardiomyopathy not otherwise specified | Natural | 1.37 |
| 1103 | 89 | 22.9 | 6.8 | 7.8 | M | W | BFT of head and trunk | Accidental | 8.12 |
| 1108 | 60 | 23.3 | 6.3 | 8.1 | M | W | ASCVD | Natural | 6.92 |
| 1114 | 29 | 11.4 | 6.8 | 9.4 | F | W | Trauma (trunk) | Accidental | −5.57 |
| 1119 | 57 | 20.2 | 6.8 | 8 | M | W | ASCVD | Natural | 8.62 |
| 1122 | 55 | 15.4 | 6.7 | 7.9 | M | W | Cardiac tamponade | Natural | 13.18 |
| 1129 | 54 | 21 | 6.8 | 9 | M | W | ASCVD | Natural | 7.91 |
| 1141 | 54 | 19.2 | 6.6 | 8.5 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 9.48 |
| 1142 | 44 | 12.3 | 5.8 | 6.1 | M | B | Hypertensive and arteriosclerotic CVD | Natural | 15.98 |
| 1144 | 75 | 21.4 | 6.7 | 7.3 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 7.75 |
| 1153 | 55 | 28 | 6.6 | 8 | M | W | Atherosclerotic and hypertensive heart disease | Natural | 3.69 |
| 1159 | 51 | 16.7 | 6.5 | 7.6 | M | W | Hypertensive heart disease | Natural | 11.81 |
| 1165 | 67 | 21 | 6.6 | 7.5 | F | W | Cardiac tamponade | Natural | 10.49 |
| 1171 | 56 | 19.2 | 6.5 | 8.5 | M | W | Cardiac tamponade | Natural | 8.55 |
| 1172 | 52 | 16.8 | 6.5 | 7.7 | F | B | Hypertensive heart disease | Natural | 11.79 |
| 1191 | 59 | 19.4 | 6.2 | 8.4 | M | B | Atherosclerotic and hypertensive heart disease | Natural | 9.24 |
| 1193 | 31 | 12.8 | 6.5 | 7.6 | M | W | Myocardial infarction due to ASCVD | Natural | 15.64 |
| 1194 | 27 | 16.4 | 6.4 | 8.8 | M | W | ASCVD | Natural | 12.63 |
| 1196 | 36 | 14.5 | 6.4 | 8.2 | F | W | Positional asphyxia | Accidental | 17.15 |
| 1201 | 52 | 16.4 | 6.2 | 8.1 | F | W | ASCVD | Natural | 12.51 |
| 1212 | 49 | 9.2 | 6.6 | 8.2 | M | B | Massive subarachnoid hemorrhage | Natural | −4.42 |
| 1214 | 57 | 16.4 | 6.4 | 7.5 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 12.56 |
| 1219 | 56 | 14.9 | 6.5 | 8.5 | M | W | ASCVD | Natural | 14.77 |
| 1237 | 64 | 8.7 | 6.4 | 7.7 | M | W | ASCVD | Natural | 0.70 |
| 1239 | 22 | 9.5 | 6.7 | 7.4 | M | W | BFT to the head and neck | Accidental | −5.42 |
| 1245 | 59 | 21.6 | 6.6 | 7.4 | M | W | ASCVD | Natural | 7.37 |
| 1247 | 58 | 22.7 | 6.4 | 8.4 | F | W | ASCVD | Natural | 8.46 |
| 1264 | 38 | 21.1 | 6.7 | 8.6 | M | W | Cardiomyopathy | Natural | 5.60 |
| 1270 | 73 | 19.7 | 6.7 | 7.7 | F | W | BFT of neck and trunk | Accidental | 8.62 |
| 1276 | 57 | 14.9 | 6 | 6.1 | F | W | Arteriosclerotic CVD | Natural | 13.90 |
| 1280 | 50 | 23.5 | 6.7 | 7.7 | F | W | Pulmonary thromboembolism | Natural | 3.95 |
| 1288 | 59 | 19.7 | 6.9 | 7.4 | M | W | Atherosclerotic and hypertensive heart disease | Natural | 9.49 |
| 1293 | 65 | 18.5 | 6.6 | 7 | F | W | BFT of trunk | Accidental | 11.51 |
| 1298 | 48 | 24.5 | 6.8 | 7.9 | M | W | ASCVD | Natural | 4.78 |
| 1300 | 56 | 16.5 | 6 | 6.9 | F | W | Pulmonary thromboembolism | Natural | 13.22 |
| 1306 | 18 | 16 | 6.6 | 7.9 | M | W | Congenital heart anomaly | Natural | 13.54 |
| 1307 | 32 | 4.8 | 6.7 | 7.6 | M | B | Hypertensive cardiomyopathy | Natural | 4.03 |
| 1308 | 58 | 20.2 | 6 | 6.2 | M | W | Hepatocellular carcinoma | Natural | 8.43 |
| 1317 | 56 | 22.9 | 6.5 | 8.8 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 4.80 |
| 1326 | 58 | 16.4 | 6.7 | 8 | M | W | ASCVD | Natural | 13.47 |
| 1333 | 46 | 18.2 | 6.8 | 8.7 | M | W | Arteriosclerotic and hypertensive CVD | Natural | 10.65 |
| 1335 | 18 | 14.6 | 7 | 8.7 | M | W | BFT of head and trunk | Accidental | 16.06 |
| 1350 | 21 | 24.2 | 6.4 | 7.3 | M | W | BFT of trunk | Accidental | 6.62 |
| 1371 | 33 | 13 | 6.2 | 8.5 | M | B | Eosinophilic myocarditis | Natural | −5.61 |
| 1374 | 43 | 21.7 | 6.6 | 7.2 | M | W | Coronary atherosclerotic disease | Natural | 7.91 |
| 1378 | 53 | 20.1 | 6.5 | 7.8 | F | B | Coronary artery disease | Natural | 8.46 |
| 1382 | 73 | 25.3 | 6.6 | 7.9 | F | W | BFT of head with ponto-midbrain transection | Accidental | 2.87 |
| 1391 | 51 | 7.8 | 6.6 | 7.1 | F | W | Atherosclerotic coronary artery disease | Natural | −0.59 |
| 1394 | 45 | 17.3 | 6.6 | 7.3 | M | W | Atherosclerotic coronary artery disease | Natural | 10.12 |
| 1400 | 50 | 16 | 5.8 | 6.8 | M | W | Coronary atherosclerotic disease | Natural | 11.40 |
| 1410 | 54 | 15.3 | 6.9 | 7.8 | M | W | Atherosclerotic coronary artery disease | Natural | 13.11 |
| 1433 | 65 | 24.1 | 6.8 | 7.5 | M | W | Acute subdural hematoma with skull fracture | Accidental | 7.18 |
| 1434 | 25 | 25.5 | 6.7 | 7.5 | M | B | Cardiac arrhythmia while exercising | Natural | 5.35 |
| 1441 | 57 | 22.3 | 6.5 | 8.5 | M | W | Arteriosclerotic CVD | Natural | 7.88 |
| 1444 | 46 | 22 | 6.5 | 8.4 | M | W | Pulmonary thromboembolus | Natural | 5.25 |
| 1447 | 51 | 16.2 | 6.5 | 8.5 | M | W | Calcified atherosclerotic coronary artery disease | Natural | 15.53 |
| 1460 | 53 | 21.3 | 6.2 | 7.3 | M | W | Severe ASCVD | Natural | 6.28 |
| 1462 | 47 | 17.2 | 6.6 | 8.5 | M | W | ASCVD | Natural | 10.58 |
| 1466 | 64 | 20 | 6.7 | 8.8 | F | B | BFT to trunk | Accidental | 9.33 |
| 1482 | 25 | 20.2 | 6.6 | 9.1 | M | W | ASCVD | Natural | 8.26 |
| 1488 | 39 | 21.5 | 6.4 | 8.7 | M | B | Bilateral pulmonary thromboemboli | Natural | 6.38 |
| 1497 | 38 | 8.5 | 6.3 | 9.1 | M | W | ASCVD | Natural | −2.80 |
| 1511 | 48 | 23.5 | 6.8 | 7.2 | M | W | Severe ASCVD | Natural | 4.30 |
| 1514 | 60 | 25 | 6.4 | 6.6 | F | W | Bilateral pulmonary emboli | Natural | 2.91 |
| 1524 | 66 | 9.4 | 6.4 | 8.1 | M | W | Acute small intestinal ischemic infarction | Natural | −4.21 |
| 1541 | 80 | 10.5 | 6.5 | 8 | M | W | Pulmonary fibrosis | Natural | 17.40 |
| 1554 | 50 | 23.2 | 6.5 | 7.6 | M | W | Acute myocardial infarction | Natural | 7.67 |
| 1555 | 17 | 15.1 | 6.9 | 7.9 | M | W | BFT to head, thorax, abdomen, right | Accidental | 16.70 |
| 1558 | 54 | 24.4 | 6.9 | 7.7 | M | W | ASCVD | Natural | 4.60 |
| 1559 | 45 | 8.9 | 6 | 6.9 | M | W | Cardiomegaly | Natural | −1.66 |
| 1564 | 48 | 19.9 | 6.8 | 7.5 | M | W | BFT to trunk | Accidental | 8.99 |
| 1574 | 52 | 26.7 | 6.3 | 7 | M | W | Bilateral pulmonary embolism | Natural | 2.07 |
| 1583 | 58 | 19.1 | 6.8 | 8.2 | M | W | BFT of the trunk | Accidental | 9.10 |
| 1598 | 50 | 23.8 | 6.9 | 7.8 | M | W | Acute myocardial infarction | Natural | 10.12 |
| 1623 | 52 | 25.7 | 6.3 | 6.6 | M | W | BFT of head and neck | Accidental | 4.86 |
| 1637 | 46 | 16.6 | 6.9 | 8.2 | M | W | Coronary artery atherosclerosis | Natural | 15.86 |
| 10003 | 49 | 21.2 | 6.5 | 8.4 | M | W | Multiple blunt force injuries | Accidental | 9.82 |
| 10005 | 42 | 23.5 | 6.7 | 7.4 | M | W | Multiple blunt force injuries | Accidental | 7.43 |
| 10013 | 16 | 9.3 | 6.7 | 9 | F | W | Trauma (multiple blunt force injuries) | Accidental | −3.88 |
| 10016 | 18 | 16.3 | 6.8 | 5.9 | M | B | Gunshot wound of abdomen | Homicide | 15.46 |
| 10021 | 38 | 12.7 | 6.3 | 7.2 | M | W | Multiple blunt force injuries | Accidental | 16.86 |
| 10027 | 53 | 13.1 | 6.2 | 6.6 | F | B | Congestive heart failure | Natural | 17.13 |
ASCVD, atherosclerotic cardiovascular disease; B, African American; BFT, blunt force trauma; CVD, cardiovascular disease; F, female; HU, subject no.; M, male; pH, brain tissue pH; PMI, postmortem interval; RIN, RNA integrity number; TOD, time of death (zeitgeber time); W, Caucasian.