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. 2015 Dec 14;113(1):26–33. doi: 10.1073/pnas.1522364112

Fig. 4.

Fig. 4.

Acute inhibition of DAGLs causes rapid and profound remodeling of bioactive lipid pathways in the brain. (A, C, E, G, I, K) Quantification of 2-AG (A) and related bioactive lipids (C, E, G, I, K) in brain tissue from mice treated with vehicle or DH376, DO34, and DO53 (50 mg/kg, i.p., 4 h). Lipid profiles from DAGLα−/− mice are shown for comparison. Data represent average values ± SEM; n = 5–6 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001 for inhibitor-treated DAGLα+/+ mice or DAGLα−/− mice vs. vehicle-treated DAGLα+/+ mice. (B, D, F, H, J, L) Time-dependent changes in 2-AG (B) and bioactive lipids (D, F, H, J, L) in brain tissue from mice treated with DH376 (50 mg/kg, i.p.). Data represent average values ± SEM; n = 4−5 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001 for inhibitor-treated vs. vehicle-treated mice.