Table 3. HIF-1α and VEGF associations with basal markers, basal-like phenotypes and subtypes.
| Variable | HIF-1α Weak (SI = 0–2) (n; %) n = 96 | HIF-1α Strong (SI = 3–9) (n; %) n = 165 | P-value | VEGF Weak (SI = 0–2) (n; %) n = 55 | VEGF Strong (SI = 3–9) (n; %) n = 130 | P-value |
|---|---|---|---|---|---|---|
| CK 5/6 expression | NS | NS | ||||
| Negative, SI = 0 | 79 (36) | 138 (64) | 45 (29) | 110 (71) | ||
| Positive, SI = 1–9 | 15 (38) | 25 (62) | 8 (29) | 20 (71) | ||
| P-cad expression | NS | NS | ||||
| Negative, SI = 0–3 | 71 (38) | 116 (62) | 41 (31) | 93 (69) | ||
| Positive, SI = 4–9 | 25 (35) | 47 (65) | 13 (26) | 37 (74) | ||
| EGFR expression | NS | NS | ||||
| Negative (≤1%) | 70 (34) | 134 (66) | 44 (30) | 102 (70) | ||
| Positive (>1%) | 24 (44) | 30 (56) | 10 (28) | 26 (72) | ||
| BLP1 | NS | NS | ||||
| Absent | 80 (36) | 141 (64) | 45 (29) | 111 (71) | ||
| Present | 13 (37) | 22 (63) | 8 (30) | 19 (70) | ||
| BLP2 | NS | NS | ||||
| Absent | 77 (38) | 128 (62) | 45 (32) | 98 (68) | ||
| Present | 18 (33) | 37 (67) | 9 (22) | 32 (78) | ||
| BLP3 | NS | NS | ||||
| Absent | 76 (35) | 140 (65) | 47 (31) | 105 (69) | ||
| Present | 18 (42) | 25 (58) | 7 (23) | 24 (77) | ||
| BLP4 (CBP) | NS | NS | ||||
| Absent | 71 (35) | 132 (65) | 42 (30) | 100 (70) | ||
| Present | 22 (40) | 33 (60) | 12 (29) | 29 (71) | ||
| BLP5 | NS | NS | ||||
| Absent | 68 (36) | 121 (64) | 42 (31) | 92 (69) | ||
| Present | 25 (37) | 43 (63) | 12 (25) | 37 (75) | ||
| TNP | NS | NS | ||||
| No | 55 (36) | 100 (65) | 33 (31) | 74 (69) | ||
| Yes | 38 (37) | 65 (63) | 21 (27) | 56 (73) | ||
| Subtype | ||||||
| Luminal A | 21 (38) | 35 (62) | 18 (38) | 29 (62) | ||
| Luminal B | 16 (27) | 43 (73) | NS | 7 (19) | 30 (81) | 0.054 |
| HER2 | 16 (44) | 20 (56) | NS | 8 (36) | 14 (64) | NS |
| Basal-like (CBP) | 22 (40) | 33 (60) | NS | 12 (29) | 29 (71) | NS |
| Unclassified | 16 (33) | 32 (67) | NS | 9 (25) | 27 (75) | NS |
CK, cytokeratin; P-cad, P-cadherin; TNP, triple negative phenotype; CBP, Core basal phenotype