Table 2. Water and small solute transport in the AQP1 mice.
| Groups | AQP1fl/fl;Cdh5-Cre- (N = 12) | AQP1fl/fl;Cdh5-Cre+ (N = 12) |
|---|---|---|
| BW (g) | 23.84±0.82 | 23.14±0.94 |
| NUF (μl) | 780.83±71.49 | 445.00±97.96** |
| Na60D (mmol/L) | 125.79±1.90 | 133.01±3.31ns |
| Na60P (mmol/L) | 143.57±1.54 | 141.85±2.57 |
| Na60D/P | 0.88±0.01 | 0.94±0.03* |
| Sodium sieving (%) | 8.71±0.96 | 0.61±2.82** |
| UFSP (μl) | 563.76±75.43 | 353.58±75.34ns |
| FWT (μl) | 217.07±32.03 | 91.42±48.23* |
| Glucose D60/D0 | 0.25±0.01 | 0.24±0.01ns |
| Urea 60 D/PBW (g) | 0.81±0.01 | 0.85±0.02ns |
NUF, total net ultrafiltration; BW, body weight; D, dialysate concentration; P, plasma concentration; V, effluent volume; 0 or 60, indicated dwell time (min); USFP, UF through small pores; FWT, free water transport
Data are expressed as mean±SE
*P < 0.05
**P ≤ 0.01 vs AQP1fl/flCdh5-Cre-
ns, not significant