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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Nat Methods. 2015 Jul;12(7):605–608. doi: 10.1038/nmeth.3450

Figure 1. Boosting statistical power by eliminating irrelevant hypotheses.

Figure 1

Figure 1

(a) The number of accepted peptide-spectrum matches (PSMs) as a function of FDR threshold for the Plasmodium data set. Searching a combined database of Plasmodium and human sequences yields more identified spectra overall (blue) but fewer Plasmodium identifications (violet) than searching just the Plasmodium database (green). (b) Similar to (a), but analyzing isoforms of SP-A alone or in conjunction with the entire human proteome.