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Follicular fluid EVs induce genes involved in cumulus expansion. COCs from mice (A) and cows (B) were matured for 16 and 24 h, respectively, followed by quantitative RT-PCR analysis of Ptgs2, Ptx3, and Tnfaip6 levels. Small-follicle EVs increased cumulus gene expression in both mouse (A) and bovine COCs (B), whereas large-follicle EVs did not. Mouse COC Tnfaip6 expression trended (P = 0.08) to increase. a,bMeans ± SEM with different superscripts are significantly different (P < 0.05).
