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. 2016 Jan 13;11(1):e0145194. doi: 10.1371/journal.pone.0145194

Fig 2. Illustration of Y. pestis SNP typing results among European victims during three centuries.

Fig 2

The flags indicate the sample origin. ES: East Smithfield, London, England; Ber: Bergen op Zoom, the Netherlands; Her: Hereford, England; SLC: Saint-Laurent-de-la-Cabrerisse, France; MP: Manching-Pichl, Southern Germany; B: Brandenburg, Northern Germany. The distance between locations MP and B is 500 km. ES1 and ES2 refer to two different genotypes found at one location. Branches 0, 1 and 2 refer to a previously published phylogenetic tree [16]. SNPs are designated to ancestral (a: green), derived (d: blue) or undetermined status (grey). The ES1-genotype was found in three human individuals, the ES2-genotype in only one; the Dutch Ber-genotype was found in six human individuals, the English Her-genotype in two, the French SLC-genotype in one [4,6]. In the present study, the German MP-genotype was detected in four human individuals, the German B-genotype in one individual. SNP s1195 (red box) is located at position 2,896,636 in the genome of Y. pestis Type strain CO92 (Genbank AL109969.1) [16]. The SNP is located within the 48bp repetitive and variable region R0664 (2,896,594–2,896,641), and was therefore recently excluded from further phylogenetic interpretation [16].