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. 2016 Jan 13;11(1):e0146074. doi: 10.1371/journal.pone.0146074

Fig 4. RISK pathway protein phosphorylation and gene expression of stem cell retention and survival.

Fig 4

The protein phosphorylation level in RISK pathway. The pAkt(A) but not Erk(B) phosphorylation level was higher in RIPoC+IPoC, RIPoC and IPoC group than that in IR group (p<0.05). The gene expression of stem cell retention (stromal cell derived factor-1 alpha, SDF-1α, p<0.05) and survival (vascular endothelium growth factor, VEGF, p<0.05) was up-regulated in RIPoC+IPoC, RIPoC and IPoC group than that in IR group(C). Group A: RIPoC+IPoC group, received the combined algorithms of RIPoC and IPoC; Group B: RIPoC group, which received 3 cycles of 30 seconds reperfusion and re-occlusion on the limb at the onset of reperfusion; Group C: IPoC group, received 3cycles of 30 seconds reperfusion and re-occlusion on the LAD; Group D: IR group, received reperfusion without interruption after ischemia; Group E: sham group, received only open chest.