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. 2015 Jul;6(7):795–826. doi: 10.4155/tde.15.34

Figure 4. . Protective mechanisms in the red blood cell membrane.

Figure 4. 

(A) CD59 inhibits C9 multimerization and formation of the membrane attack complex by binding to nascent C5b-C8 complexes; (B) DAF inhibits early complement pathways by displacing C2a and Bb from C4b and C3b, respectively; (C) CD47 inhibits phagocytosis by macrophages through interaction with SIRPA and downstream upregulation of tyrosine phosphatase activity; (D) bone marrow aspirate from a patient with a hemophagocytic syndrome demonstrating engulfment of multiple erythrocytes (arrowheads) by a macrophage.