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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Pharmacogenomics. 2015 Dec 15;17(2):147–162. doi: 10.2217/pgs.15.156

Figure 1.

Figure 1

Location of CYP2A6 gene and commonly genotyped variants. A. CYP2A6 within the CYP2 cluster of genes on chromosome 19 (modified from Hoffman and Hu, 2007). B. CYP2A6 gene indicating exons 1–9 (numbered boxes), commonly genotyped variants (* alleles) and gene-specific 5′ and 3′ region amplicons utilized as template in allele-specific SYBR green assays (Methods 2.1). The CYP2A6*12, *34 genotyping assays use a modified version of the 5′ region amplicon (Method 2.2). CYP2A6-CYP2A7 crossover positions are illustrated for the hybrid/deletion alleles, CYP2A6*12, *34, *4 and *1B. C. Description of commonly genotyped CYP2A6 variants including variation in reference gene template and amino acid sequence (if applicable).