Table 4.
Israeli cohort demographics, characteristics, and ADNP measurements of participants.
| Cohort | Age | MMSE | Sex | ||||
|---|---|---|---|---|---|---|---|
| Mean | SD | Range | Mean | SD | Range | %Males | |
| CN | 61.7 | 5.4 | 51–72 | * | * | * | 0 |
| MCI | 71.7 | 9.8 | 60–84 | 27.3 | 1.4 | 25–29 | 80 |
| AD dementia | 75.6 | 8.4 | 59–89 | 20.6 | 5.4 | 11–29 | 37.5 |
| ADNP mRNA | ADNP2 mRNA | n | |||||
| CN | 0.44 | 0.29 | 0.13–0.88 | 0.88 | 0.67 | 0.16–1.82 | 10* |
| MCI | 0.77 | 0.47 | 0.11–1.39 | 0.29 | 0.16 | 0.04–0.53 | 12* |
| AD dementia | 3.64 | 3.0 | 0.57–10.11 | 1.59 | 1.16 | 0.32–3.61 | 17 |
| ADNP/ADNP2 mRNA | ADNP (ng/μl protein) | ||||||
| CN | 0.89 | 0.61 | 0.14–1.77 | 0.047 | 0.002 | 0.035–0.05*** | 7* |
| MCI | 2.82 | 1.36 | 0.29–30** | 0.059 | 0.013 | 0.039–0.085 | 15 |
| AD dementia | 2.32 | 0.79 | 1.14–4.19 | 0.054 | 0.015 | 0.037–0.09 | 16* |
AD (Alzheimer’s disease), ADNP (activity-dependent neuroprotective protein), CN (cognitively normal), MCI (mild cognitive impairment), MMSE (Mini-Mental State Examination), mRNA (messenger ribonucleic acid).
*
Values were not available for all participants.
**
A value of 30 was a significant outlier and was removed.
***
A value of 0.035 was a significant outlier and was removed.