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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: FEBS J. 2015 Nov 6;283(1):112–129. doi: 10.1111/febs.13556

FIGURE 3.

FIGURE 3

Determination of the mode of Inhibition. Deamination of an ss-deoxyoligonucleotide substrate concentration in the presence of Vif-derived peptides Vif107-115 (A), A3F-derived peptides A3F304-312 (B) and A3F305-311(C) was determined and is shown by double-reciprocal plot. The Vif- and A3F-derived peptide concentrations used are indicated. Vif, Vif25-39, A3F304-312 and A3F305-311 reveal an uncompetitive inhibition mode, whereas Vif105-119 and Vif107-115 inhibit A3G in a mixed mode. Values represent the average of triplicates. SD values were less than ± 0.5.