Table 1.

Case-control analyses on the association of preexisting cardiovascular risk factors and cardiovascular disease with hysterectomy with ovarian conservation in the overall sample (3,816 cases; 3,816 controls)

Risk Factor or Disease	Women with Hysterectomy n (%)	Referent Women n (%)	Univariable Analyses			Multivariable Analysesa
			OR	95% CI	p-value	OR	95% CI	p-value
Cardiovascular risk factor
Diabetes	89 (2.3)	93 (2.4)	0.96	(0.71-1.28)	0.76	0.84	(0.62-1.13)	0.25
Hyperlipidemia	135 (3.5)	98 (2.6)	1.41	(1.08-1.84)	0.01	1.27	(0.96-1.67)	0.09
Hypertension	307 (8.0)	267 (7.0)	1.19	(0.99-1.44)	0.06	1.06	(0.87-1.28)	0.56
Obesity	637 (16.7)	469 (12.3)	1.44	(1.26-1.64)	<0.001	1.42	(1.24-1.62)	<0.001
Metabolic syndromeb	59 (1.5)	32 (0.8)	1.93	(1.23-3.02)	0.004	...	...	...
Polycystic ovary syndrome	10 (0.3)	6 (0.2)	1.67	(0.61-4.59)	0.32	1.42	(0.51-3.95)	0.50
Cardiovascular disease
CAD	47 (1.2)	44 (1.2)	1.07	(0.70-1.64)	0.74	...	...	...
CHF	7 (0.2)	16 (0.4)	0.44	(0.18-1.06)	0.07	...	...	...
Myocardial infarction	12 (0.3)	14 (0.4)	0.86	(0.40-1.85)	0.70	...	...	...
Cardiac disease compositec	55 (1.4)	56 (1.5)	0.98	(0.66-1.45)	0.92	...	...	...
Stroke	27 (0.7)	28 (0.7)	0.96	(0.57-1.64)	0.89	...	...	...
CVD composited	76 (2.0)	75 (2.0)	1.01	(0.73-1.42)	0.93	...	...	...

OR, odds ratio; CI, confidence interval; CAD, coronary artery disease; CHF, congestive heart failure; CVD, cardiovascular disease.

^aCardiovascular risk factors were evaluated in a full multivariable logistic regression model that included diabetes, hyperlipidemia, hypertension, obesity, and polycystic ovary syndrome. Metabolic syndrome was not included because it was defined using variables already included in the model.

^bMetabolic syndrome was defined indirectly as 3 or more of the following 4 conditions: hyperlipidemia, hypertension, diabetes, or obesity, or as a diagnosis of metabolic syndrome.

^cThe cardiac disease composite included CAD, myocardial infarction, and CHF.

^dThe CVD composite included CAD, myocardial infarction, CHF, and stroke.