TABLE 2.

Relationship between age and brain volumes in a cross-sectional sample of men (n=1786) and women (n=2517)

	Volumes not adjusted to ICV*				Volumes adjusted to ICV*
	Men		Women		Men		Women
Tissue	Volume mean (ml)±SD	r	Volume mean (ml)±SD	r	Volume mean (%)±SD	r	Volume mean (%)±SD	r
TBP	1142.79±94.20	−0.32	1039.18±83.73	−0.31	70.78±3.73	−0.41	73.21±3.65	−0.44
GM	708.08±60.92	−0.38	654.10±53.61	−0.35	43.89±3.10	−0.39	46.12±3.06	−0.38
NWM	413.17±45.27	−0.28	366.44±39.07	−0.30	25.56±1.93	−0.34	25.79±1.80	−0.41
TWM	434.71±45.53	−0.16	385.08±40.01	−0.18	26.89±1.77	−0.18	27.09±1.68	−0.25
CSF	473.28±78.58	0.29	381.22±63.84	0.33	29.22±3.73	0.41	26.79±3.65	0.44
WMH	21.53±20.86	0.29	18.64±19.30	0.29	1.33±1.28	0.30	1.31±1.33	0.29

ICV=Intra-cranial volume; TBP=Total brain parenchyma; GM=Grey matter; NWM; Normal white matter; WMH=White matter hyperintensities; TWM=Total white matter; CSF=Cerebral-spinal fluid; SD=Standard deviation; r = Spearman correlation coefficient; ml=milliliters. Volumes not adjusted to ICV are presented as absolute and volumes adjusted to ICV are presented as percent of the total ICV.

^*Significant correlations between age and volumes were observed for all tissue types (p<0.0001), both in volumes unadjusted to ICV and adjusted to ICV for both sexes. The volume of TBP was defined as the sum of GM, NWM and WMH and the ICV was defined as the sum of TBP and CSF. Total WM (TWM) volume was defined as the sum of NWM and WMH.