Table 1.

Effects of single oral pretreatment with 20 mg kg⁻¹ of M-2 or M-3 on blood pressure during 90 min of the left anterior coronary occlusion and 15 min of reperfusion in rats

Experimental group	Continuous blood pressure measurement (mmHg) (mean ± SD)
	Occlusion (90 min)									Reperfusion (15 min)
	5 min	15 min	25 min	35 min	45 min	55 min	65 min	75 min	85 min	95 min	105 min
	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd	BPs/BPd
Control n = 4/7 [MI 42.8 %]	142 ± 10 116 ± 9.1	141 ± 33 114 ± 25	124 ± 31 100 ± 27	123 ± 41 92 ± 28	122 ± 46 97 ± 39	133 ± 38 98 ± 43	133 ± 38 107 ± 35	115 ± 23 80 ± 11	113 ± 19 83 ± 14	140 ± 26 157 ± 51	139 ± 13 107 ± 6
DMSO n = 10/13 [MI 23.1 %]	140 ± 17 114 ± 16	137 ± 28 111 ± 24	138 ± 30 111 ± 30	130 ± 38 103 ± 38	121 ± 36 94 ± 38	121 ± 30 95 ± 32	124 ± 31 96 ± 35	129 ± 33 102 ± 36	130 ± 28 103 ± 31	113 ± 16 86 ± 19	115 ± 21 87 ± 26
M-2 n = 10/12 [MI 16.6 %]	138 ± 14 111 ± 14	144 ± 17 116 ± 14	136 ± 22 110 ± 19	136 ± 16 111 ± 15	130 ± 22 103 ± 20	121 ± 27 95 ± 23	124 ± 23 96 ± 17	124 ± 22 97 ± 17	121 ± 23 96 ± 18	115 ± 22 91 ± 20	124 ± 26 96 ± 21
M-3 n = 10/12 [MI 16.6 %]	146 ± 20 117 ± 16	147 ± 10 118 ± 6	145 ± 17 113 ± 16	138 ± 19 108 ± 20	131 ± 19 99 ± 21	133 ± 14 100 ± 16	129 ± 18 98 ± 19	123 ± 29 95 ± 29	126 ± 29 99 ± 30	124 ± 16 97 ± 20	127 ± 20 98 ± 25

In the first column the data indicates number of rats that survived/number of animals in the group at the start of the experiment and in parentheses mortality index (MI) was given. The differences in BP values between the groups [systolic (BPS) and diastolic (BPd)] were calculated using non-parametric Kruskal–Wallis ANOVA test with appropriate post hoc test