Table 2.

Effects of single oral pretreatment with 20 mg kg⁻¹ of M-2 or M-3 on ST-segment changes during 90 min of left anterior coronary occlusion and 15 min of reperfusion in rats

Experimental group	ST-segment estimation (J point (mm)) (mean ± SD)
	Before	Occlusion
	1 min	5 min	10 min	20 min	30 min	40 min	50 min	60 min	70 min	80 min	90 min
Control n = 4/7	−0.05 ± 0.06	−0.027 ± 0.105	−0.022 ± 0.021	0.132 ± 0.204	0.092 ± 0.147	0.082 ± 0.159	0.07 ± 0.120	0.01 ± 0.145	0.055 ± 0.151	0.085 ± 0.179	0.11 ± 0.16
DMSO n = 10/13	−0.021 ± 0.044	−0.02 ± 0.042	−0.009 ± 0.028	0.082 ± 0.109	0.083 ± 0.101	0.073 ± 0.026	0.073 ± 0.083	0.079 ± 0.099	0.079 ± 0.099	0.064 ± 0.091	0.051 ± 0.055
M-2 n = 10/12	−0.015 ± 0.03	−0.006 ± 0.07	−0.007 ± 0.01	0.086 ± 0.1	0.095 ± 0.11	0.09 ± 0.11	0.101 ± 0.13	0.119 ± 0.15	0.114 ± 0.15	0.096 ± 0.15	0.096 ± 0.12
M-3 n = 10/12	−0.041 ± 0.047	−0.02 ± 0.043	0.0 ± 0.062	0.061 ± 0.125	0.158 ± 0.318	0.067 ± 0.12	0.076 ± 0.042	0.081 ± 0.134	0.07 ± 0.122	0.073 ± 0.117	0.088 ± 0.118

Experimental group	ST-segment estimation (J point (mm)) (mean ± SD)
	Reperfusion
	100 min	105 min
Control n = 4/7	0.095 ± 0.119	0.075 ± 0.116
DMSO n = 10/13	0.05 ± 0.073	0.047 ± 0.074
M-2 n = 10/12	0.045 ± 0.09	0.042 ± 0.09
M-3 n = 10/12	0.066 ± 0.148	0.06 ± 0.141

The differences in ST-segment changes was calculated using non-parametric Kruskal–Wallis ANOVA test with appropriate post hoc test. For other details see Table 1 and text