Table 1.
Group | Glu (mmol L−1) | BW (g) | KW/BW (g/100 g) | UAERa (mg·24 h−1) |
---|---|---|---|---|
Normal | 6.88 ± 0.81 | 351.6 ± 15.40 | 0.30 ± 0.04 | 0.29×/÷1.1 |
Control diabetic | 26.80 ± 2.98** | 224.2 ± 13.20** | 0.51 ± 0.04* | 0.95×/÷1.2** |
Control diabetic + FK506 0.5 mg/kg | 27.10 ± 2.44** | 227.8 ± 12.64** | 0.46 ± 0.05* | 0.78×/÷1.1*,# |
Control diabetic + FK506 1.0 mg/kg | 27.22 ± 2.35** | 258.2 ± 18.87** | 0. 34 ± 0.06# | 0.55×/÷1.1**,## |
Data are expressed as mean ± SEM. Number of rats in each group was 10. A shown as geometric mean tolerance factor
Glu glucose, BW body weight, KW/BW kidney-to-body weight ratio, UAER urinary albumin excretion rate
* p < 0.05 compared with normal group; ** p < 0.01 compared with normal group; # p < 0.05 compared with control diabetic group; ## p < 0.01 compared with control diabetic group