Table 1.

Clinical history, autopsy finding, and molecular genetic evaluation of 15 sudden unexplained death victims in Sweden 2009–2011, 1–35 years of age

ID	Age	Sex	Activity	Details of event	Clinical history	Investigation	Family history	Autopsy findings	Genetic findings	Familial cascade screening	Diagnosis
1	28	F	Unknown	Found deceased at home Not witnessed	Syncope 2 days before death Medication: mirtazapine	No ECG Clinical examination	Unknown	Inflammatory changes in the heart	KCNQ1 p. Q220K	1 neg (adopted)	LQTS
2	8	F	Sleep	Found deceased at home Not witnessed Infection	Healthy	None	None	Normal heart	KCNQ1 p. H240R	3 pos/1 neg	LQTS
3	18	M	Unknown	Found deceased on the floor at home Not witnessed	Had a drinking problem Medication: alprazolam, alimemazine. Had a cold 2 weeks before death	None	None	Normal heart. Ethanol in femoral blood (1.06‰), alprazolam, alimemazine in therapeutic concentrations	KCNQ1 p. A370V	4 pos/3 neg	LQTS
4	14	M	Sitting	Collapsed in school Witnessed	ADHD medication: tomoxetine	None	Unknown	Normal heart	KCNH2 p. S668L	None (adopted)	LQTS
5	18	M	Physical activity	Collapsed at the bus stop Witnessed	Cardiac arrest 3 years before death High blood pressure Fever spells in childhood and suspected seizures as teenager	ECG, cardiac ultra sound and EEG normal	Sister, grand grandfather and grand uncle SUD	Normal heart	RYR2 p. S4168T	3 pos/3 neg	CPVT
6	14	M	Physical activity	Drowning Not witnessed	Healthy	None	None	Normal heart	RYR2 p. D401G De novo	3 neg	CPVT
7	18	M	Sleep	Found deceased at home Not witnessed	Tachycardia 1½ years before death	None No ECG	None	Normal heart	None	–	Causa mortis ignota
8	17	M	Sleep/rest	Found deceased at home Not witnessed	Seizure 1 week before death Had a cold 3 weeks before death	No ECG	None	Normal heart	None	–	Causa mortis ignota
9	2	M	Sleep	Found deceased at home Not witnessed	1 year before death sudden un-consciousness and falling from a bobby car	None	None	Normal heart	None	–	Causa mortis ignota
10	3	M	Sleep	Found deceased at home Not witnessed	Infection the day before death, fever seizures earlier	None	Father seizure, grandfather SUD	Normal heart	None	–	Causa mortis ignota
11	18	M	Sleep	Found deceased at home Not witnessed	Vomiting and palpitations some days before death	None	None	Normal heart	None	–	Causa mortis ignota
12	17	F	Sleep/rest	Found deceased at home Not witnessed	Vomiting, headache, and dizziness during the night before death	None	None	Normal heart	None	–	Causa mortis ignota
13	18	M	Sleep	Found deceased at home Not witnessed	The night before death vomiting, and hard physical activity	None	None	Normal heart In urine: metandienon; 945 ng/ul	None	–	Causa mortis ignota
14	17	M	Sleep	Found deceased at home Not witnessed	Diabetes	None	None	Normal heart, glucose, and lactate normal concentrations	None	–	Causa mortis ignota
15	22	F	Driving	Car accident Included because no injury that could explain the death	Pregnant	None	None	Normal heart	None	–	Causa mortis ignota

ECG electrocardiogram, LQTS long QT syndrome, ADHD attention deficit hyperactivity disorder, EEG electroencephalogram, SUD sudden unexpected death, CPVT catecholaminergic polymorphic ventricular tachycardia, Causa mortis ignota death cause unknown