Table 3.
Relationship between cerebral blood flow (CBF) and cognition (Mini-Mental State Examination scores)
| Across groups | Control | Predementia | AD | ||
|---|---|---|---|---|---|
| Stage 0 | Stage 1 | Stage 2 | Stage 3 | ||
| Uncorrected whole brain CBF | 0.33** | −0.01 | 0.22 | −0.20 | 0.21+ |
| PVC cortical CBF | 0.27** | −0.02 | 0.30 | −0.21 | 0.19 |
| Regional uncorrected cortical CBF | |||||
| Frontal | 0.23* | −0.06 | −0.03 | 0.05 | 0.18 |
| Temporal | 0.38** | 0.02 | 0.22 | −0.03 | 0.21+ |
| Parietal | 0.40 | −0.01 | 0.22 | 0.16 | 0.24+ |
| PPC | 0.40** | 0.03 | 0.28 | −0.17 | 0.17 |
| Occipital | 0.34** | 0.12 | 0.25§ | −0.35+ | 0.18 |
| Cerebellum | 0.09 | −0.05 | 0.24 | −0.30 | −0.04 |
| Regional PVC cortical CBF | |||||
| Frontal | 0.24* | −0.07 | 0.18 | −0.21 | 0.23+ |
| Temporal | 0.31** | −0.02 | 0.26 | −0.13 | 0.22+ |
| Parietal | 0.32** | −0.02 | 0.41 | −0.18 | 0.21+ |
| PPC | 0.29** | 0.01 | 0.46 | −0.28 | 0.16 |
| Occipital | 0.23* | 0.04 | 0.44 | −0.30 | 0.11 |
| Cerebellum | 0.08 | −0.04 | 0.13 | −0.05 | 0.02 |
*p<0.01, **p<0.001, +p<0.1; adjustment for age and sex (model 1)
§A relationship between cognition and uncorrected CBF in the occipital lobes (standardized beta 0.70; p<0.05) was detected after additional adjustment for white matter hyperintensities (Fazekas-scores; model 2)
Stage 0: Aβ-/tau- patients with subjective complaints (SC), Stage 1: Aβ+/tau- patients with SC and mild cognitive impairment (MCI), Stage 2: Aβ+/tau+ patients with SC and MCI, Stage 3: Aβ+/tau+ patients with AD
AD Alzheimer’s disease, PPC precuneus and posterior cingulated, PVC partial volume corrected