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. 2015 Jun 28;55:79–91. doi: 10.1007/s40262-015-0294-y

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Intra-individual change of metabolic ratios of the Basel cocktail probe drugs after pretreatment with the CYP inducer rifampicin compared with baseline. A consistent increase of metabolic ratios was observed for CYP1A2 (except for three subjects) (a), and a consistent decrease for CYP2B6 (except for one subject) (b), CYP2C19 (d), and CYP3A4 after deglucuronidation (f). The metabolic ratios of CYP2C9 (c), and CYP2D6 (e) only showed small and inconsistent changes after induction. Metabolic ratios of subjects with altered function alleles are shown using open symbols. CYP cytochrome P450 enzyme