Figure 4.

Increased inhibition during Up state terminations. (Top) Synaptic inputs are assumed to be predominately shared between nearby (<500 μm) cortical neurons. In recordings with a KAc pipette, inhibition should be hyperpolarizing or shunting, while in recordings with a KCl pipette, inhibition should be depolarizing. Thus, differences between the membrane potential excursions in KAc-KCl dual recordings should predominately reflect inhibition. (Bottom) Dual KAc-KCl recording in sleeping cat cortex. Periods of inhibition (shaded regions) occur above a pre-determined threshold primarily before Up state termination. Adapted by permission from the American Physiological Society: Journal of Neurophysiology (Lemieux et al., 2015), © 2015.