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. 2016 Jan 14;9:516. doi: 10.3389/fnins.2015.00516

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Copyright © 2016 Cheung, Schultz and Luk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulation using NeuroFlow with STDP enabled under the paired stimulation protocol. (A) The simulation consists of two aEIF neurons which are mutually connected. Each of them receives an alternate stimulation of 10 mA for 250 ms. (B) The STDP profile used for the simulation, with A₊ = 0.1, A₋ = 0.12 and τ₊ = τ₋ = 20 ms (C) Traces of membrane voltage of the two neurons with spike time difference of 10 ms. The neurons spike upon receiving the external stimulation, where blue (red) arrows correspond to the time when neuron a (neuron b) receives external stimulation in the diagram. (D) Evolution of the strength of synaptic coupling between the two neurons across time in the trial described in (C).