Algorithm 1.

Synchronous-Asynchronous Release STP Model.

Sync. release probability:	$\begin{array}{l}\frac{\text{d}{u}_{\text{sr}}\left(t\right)}{\text{d}t}=-\frac{u_{\text{sr}}\left(t\right)}{{\tau }_{\text{sr}}}+U_{\text{sr}}\left[1-u_{\text{sr}}\left(t\right)\right]\\ {\displaystyle \sum _m\delta }\left(t-t_m\right)\end{array}$
Async. rel. probability rate:	$\begin{array}{l}\frac{\text{d}{u}_{\text{ar}}\left(t\right)}{\text{d}t}=-\frac{u_{\text{ar}}\left(t\right)}{{\tau }_{\text{ar}}}\text{ }+\text{ }{U}_{\text{ar}}\left[U_{\text{max}}\text{}-\text{ }{u}_{\text{ar}}\left(t\right)\right]\\ {\displaystyle \sum _m\delta }\left(t-t_m\right)\end{array}$
Sync. release rate:	$q_{\text{sr}}(t)=x_0{n}_{\text{sr}}(t){\displaystyle \sum _m\delta }\left(t-t_m\right)$
Async. release rate:	$q_{\text{ar}}(t)\text{d}t=x_0{n}_{\text{ar}}(t)$
Available vesicle number:	$\begin{array}{l}\text{d}N(t)=r(t)-n_{\text{ar}}(t)-n_{\text{sr}}(t)\\ {\displaystyle \sum _m\delta }\left(t-t_m\right)\text{d}t\end{array}$
Vesicles replenishment:	$r(t)~\mathcal{B}\left(N_F-N(t),\text{ d}t/{\tau }_d\right)$
Sync. released vesicles:	$n_{\text{sr}}(t)~\mathcal{B}\left(N(t),u_{\text{sr}}(t_{+})\right)$
Async. released vesicles:	$n_{\text{ar}}(t)~\mathcal{B}\left(N(t),u_{\text{ar}}(t)\text{d}t\right)$