Table 4. Effects of DR on mean and maximal longevity of rpd3P-UTR/+ (Top) and rpd3P-1.8/+ (Bottom) flies.
| Gender | Genotype | Food (N) | Number | Mean Lifespan (% Change to controls) | X2 | p | Maximal Lifespan (% Change) |
|---|---|---|---|---|---|---|---|
| M | rpd3P-UTR/+ | 1.0 | 219 | 57.4 | 72.61 | ||
| M | rpd3P-UTR/+ | 0.1 | 237 | 17.6 (−70) | 506.18 | <0.001* | 26.1(−64) |
| M | rpd3P-UTR/+ | 0.3 | 206 | 58.1 (1) | 0.0011 | 0.9732 | 71.1 (−2) |
| M | rpd3P-UTR/+ | 0.5 | 225 | 62.4 (8) | 31.336 | <0.001* | 85.7 (18) |
| M | rpd3P-UTR/+ | 0.7 | 213 | 58.7 (2) | 6.6398 | 0.0100* | 74.6 (3) |
| M | rpd3P-UTR/+ | 1.5 | 231 | 60.0 (4) | 8.9391 | 0.0028 | 76.8 (6) |
| M | rpd3P-UTR/+ | Corn | 218 | 68.1 (19) | 129.48 | <0.001* | 82.6 (14) |
| F | rpd3P-UTR/+ | 1.0 | 223 | 63.0 | 79.4 | ||
| F | rpd3P-UTR/+ | 0.1 | 219 | 23.6 (−62) | 423.72 | <0.001* | 48.7 (−39) |
| F | rpd3P-UTR/+ | 0.3 | 199 | 61.9 (−2) | 0.7415 | 0.3892 | 80.7 (2) |
| F | rpd3P-UTR/+ | 0.5 | 218 | 72.4 (15) | 90.451 | <0.001* | 89.2 (12) |
| F | rpd3P-UTR/+ | 0.7 | 232 | 68.8 (9) | 52.246 | <0.001* | 85.5 (8) |
| F | rpd3P-UTR/+ | 1.5 | 226 | 63.0 (0) | 1.4257 | 0.2325 | 80.6 (2) |
| F | rpd3P-UTR/+ | Corn | 230 | 57.0 (−10) | 2.8411 | 0.0919 | 88.8 (12) |
| M | rpd3P-1.8/+ | 1.0 | 228 | 54.2 | 70.9 | ||
| M | rpd3P-1.8/+ | 0.1 | 70 | 11.6 (−79) | 437.4 | <0.001* | 15.4 (−78) |
| M | rpd3P-1.8/+ | 0.3 | 226 | 54.5 (0) | 4.0704 | 0.0436* | 66.6 (−6) |
| M | rpd3P-1.8/+ | 0.5 | 223 | 58.7 (8) | 19.005 | <0.001* | 74.4 (5) |
| M | rpd3P-1.8/+ | 0.7 | 227 | 60.3 (11) | 53.962 | <0.001* | 75.6 (7) |
| M | rpd3P-1.8/+ | 1.5 | 228 | 58.0 (7) | 19.156 | <0.001* | 73.5 (4) |
| M | rpd3P-1.8/+ | Corn | 227 | 65.5 (21) | 126.69 | <0.001* | 87.8 (24) |
| F | rpd3P-1.8/+ | 1.0 | 216 | 56.2 | 69.9 | ||
| F | rpd3P-1.8/+ | 0.1 | 58 | 15.6 (−72) | 398.44 | <0.001* | 23.2 (−67) |
| F | rpd3P-1.8/+ | 0.3 | 225 | 61.0 (8) | 26.974 | <0.001* | 78 (12) |
| F | rpd3P-1.8/+ | 0.5 | 224 | 64.0 (14) | 80.351 | <0.001* | 77.5 (11) |
| F | rpd3P-1.8/+ | 0.7 | 224 | 67.3 (20) | 163.90 | <0.001* | 80.8 (16) |
| F | rpd3P-1.8/+ | 1.5 | 230 | 56.6 (1) | 0.3637 | 0.5465 | 71.4 (2) |
| F | rpd3P-1.8/+ | Corn | 224 | 55.0 (−2) | 1.2871 | 0.2566 | 76.1 (9) |
The mean and maximal lifespan of male (M) and female (F) rpd3P-UTR/+ (Top) and rpd3P-1.8/+ (Bottom) control flies on different food levels. All values are compared to values obtained for flies of the same sex and the same genotype kept on 1.0N food to determine the percent increase in mean and maximal lifespan. Food (N): standard food is 1.0N. Number: number of flies used in the experiment. Mean and maximal lifespan are in days. Data are censored for 0-10 days. Long-rank analyses were performed using the JMP 11 program.