Table 5. Effect of 4E-BP mutation on longevity of flies on different food levels.
| Gender | Genotype | Food (N) | Number | Mean Lifespan (% Change to controls) | X2 | p | Maximal Lifespan (% Change) |
|---|---|---|---|---|---|---|---|
| M | +/+ | 1.0 | 273 | 52.7 | 73.8 | ||
| M | Thork07736/+ | 1.0 | 209 | 42.8 (−19) | 55.70 | <0.001* | 66.1 (−10) |
| M | +/+ | 0.5 | 286 | 51.7 | 72.6 | ||
| M | Thork07736/+ | 0.5 | 231 | 49.2 (−5) | 5.62 | 0.0178* | 66 (−8) |
| M | +/+ | 0.7 | 277 | 51.1 | 73.5 | ||
| M | Thork07736/+ | 0.7 | 221 | 47.6 (−7) | 9.68 | 0.0019* | 69.8 (−5) |
| M | +/+ | 1.5 | 277 | 43.3 | 64.93 | ||
| M | Thork07736/+ | 1.5 | 201 | 41.8 (−3) | 3.38 | 0.0658 | 58.3 (−10) |
| M | +/+ | Corn | 280 | 54.0 | 71.8 | ||
| M | Thork07736/+ | Corn | 220 | 42.8 (1) | 3.58 | 0.0583 | 79.0 (10) |
| F | +/+ | 1.0 | 273 | 57.6 | 74.2 | ||
| F | Thork07736/+ | 1.0 | 226 | 38.3 (−33) | 317.08 | <0.001* | 56.0 (−25) |
| F | +/+ | 0.5 | 247 | 59.9 | 78.9 | ||
| F | Thork07736/+ | 0.5 | 231 | 54.6 (−9) | 22.99 | <0.001* | 72 (−8) |
| F | +/+ | 0.7 | 282 | 52.5 | 71 | ||
| F | Thork07736/+ | 0.7 | 234 | 54.3 (3) | 12.69 | 0.0004* | 74.5 (5) |
| F | +/+ | 1.5 | 284 | 42.7 | 59.6 | ||
| F | Thork07736/+ | 1.5 | 220 | 37.5 (−12) | 36.98 | <0.001* | 52.9 (−11) |
| F | +/+ | Corn | 273 | 58.6 | 75.9 | ||
| F | Thork07736/+ | Corn | 222 | 59.4 (1) | 4.26 | 0.039 | 78.0 (3) |
The mean and maximal lifespan of male (M) and female (F) +/+ control and 4E-BP (Thork07736/+) mutant flies on different food levels. All +/+ values are compared to values of Thork07736/+ group on the same food level and same sex to determine the percent increase in mean and maximal lifespan in 4E-BP mutant flies. Food (N): standard food is 1.0N. Number: number of flies used in the experiment. Mean and maximal lifespan are in days. Data are censored for 0-10 days. Long-rank analyses were performed using the JMP 11 program.