Table 7. 4E-BP (Thork07736) mutation affects longevity of rpd3def/+ flies on different food levels.
| Gender | Genotype | Food (N) | Number | Mean Lifespan (% Change to controls) | X2 | p | Maximal Lifespan (% Change) |
|---|---|---|---|---|---|---|---|
| M | rpd3def/+ | 1.0 | 236 | 70.6 | 93.5 | ||
| M | Thork07736/+;rpd3def/+ | 1.0 | 256 | 64.3 (−9) | 142.91 | <0.001* | 88.8 (−5) |
| M | rpd3def/+ | 0.5 | 247 | 68.8 | 3.6229 | 0.57 | 95.8 |
| M | Thork07736/+;rpd3def/+ | 0.5 | 259 | 65.9 (−4) | 237.93 | <0.001* | 87.4 (−9) |
| M | rpd3def/+ | 0.7 | 243 | 75.2 | 16.912 | <0.001* | 103.6 |
| M | Thork07736/+;rpd3def/+ | 0.7 | 244 | 64.7 (−14) | 101.36 | <0.001* | 87.0 (−16) |
| M | rpd3def/+ | 1.5 | 254 | 61.2 | 58.619 | <0.001* | 84 |
| M | Thork07736/+;rpd3def/+ | 1.5 | 228 | 57.1 (−7) | 118.91 | <0.001* | 75.1 (11) |
| M | rpd3def/+ | Corn | 240 | 76.5 | 21.005 | <0.001* | 105.3 |
| M | Thork07736/+;rpd3def/+ | Corn | 242 | 68.5 (10) | 124.82 | <0.001* | 90.9 (14) |
| F | rpd3def/+ | 1.0 | 269 | 70.8 | 95.5 | ||
| F | Thork07736/+;rpd3def/+ | 1.0 | 276 | 64.8 (−8) | 130.99 | <0.001* | 89.0 (−7) |
| F | rpd3def/+ | 0.5 | 259 | 70.4 | 4.6814 | 0.0305* | 84.1 |
| F | Thork07736/+;rpd3def/+ | 0.5 | 274 | 68.6 (−3) | 164.07 | <0.001* | 87.9 (5) |
| F | rpd3def/+ | 0.7 | 251 | 79.6 | 40.489 | <0.001* | 102.8 |
| F | Thork07736/+;rpd3def/+ | 0.7 | 275 | 69.9 (−12) | 105.99 | <0.001* | 94.5 (−8) |
| F | rpd3def/+ | 1.5 | 278 | 51.5 | 266.83 | <0.001* | 71 |
| F | Thork07736/+;rpd3def/+ | 1.5 | 263 | 49.5 (−4) | 16.049 | <0.001* | 70.1 (0) |
| F | rpd3def/+ | Corn | 241 | 62.8 | 21.061 | <0.001* | 88.8 |
| F | Thork07736/+;rpd3def/+ | Corn | 258 | 62.2 (−1) | 5.401 | 0.0201* | 78 (−12) |
The mean and maximal lifespan of male (M) and female (F) rpd3def/+ and Thork07736/+;rpd3def/+ mutant flies on different food levels. All rpd3def/+ values are compared to Thork07736/+;rpd3def/+ value mutant of the same sex and on the same food level to determine the percent increase in mean and maximal lifespan. Food (N): standard food is 1.0N. Number: number of flies used in the experiment. Mean and maximal lifespan are in days. Data are censored for 0-10 days. Long-rank analyses were performed using the JMP 11 program.