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. 2015 Dec 9;7(12):1130–1142. doi: 10.18632/aging.100859

Figure 4. Blood cell counts versus PD status.

Figure 4

As indicated in the heading of each panel, the panels alternate between the two data sets. PD status (x-axis) versus (A,B) proportion of cytotoxic CD8+ T cells, (C,D) naïve CD8+ T cell count, (E,F) percentage of exhausted CD8+ T cells (defined as CD8+CD28-CD45RA-), (G,H) proportion of helper CD4+ T cells, (I,J) naïve CD4+ T cell count, (K,L) proportion of natural killer cells, (M,N) proportion of monocytes, (O,P) granulocytes, (Q,R) B cells, (S,T) plasma blasts (activated B cells). The abundance measures of blood cell counts were estimated based on DNA methylation levels using the epigenetic clock software. The y-axis of (E,F) reports a percentage, that of (C,D,I,J) a cell counts but it is best to interpret these measures as ordinal abundance measures. The y-axis of the other panels reports estimated proportions based on the Houseman method [45]. Each bar plot depicts the mean value (y-axis), 1 standard error, and the group size (underneath the bar). The p-value results from a non-parametric group comparison test (Kruskal Wallis).