Table 1. Multivariate model of DNAm age in non-centenarians.

Covariate	Coefficient	Std. Error	T statistic	P-value
Offspring	−3.804	1.043	−3.647	0.00043
Age	0.743	0.071	10.442	< 2×10−16
Sex (female)	0.174	1.065	0.163	0.87
Naïve CD8+T cell	−0.007	0.011	−0.617	0.54
Exhausted CD8+ T cell	−0.044	0.159	−0.274	0.79
Plasma Blast cell	−7.62	3.706	−2.055	0.042
Helper T cell (CD4)	−28.3	8.728	−3.247	0.0016
Natural Killer cell	12.5	7.962	1.572	0.13
Monocyte	−9.2	9.313	−0.988	0.33

Coefficients and p-values from regressing DNAm age on offspring status, age, sex, and various blood cell counts in non-centenarian subjects (subjects younger than 90). The model explained 67% of the variance. The offspring of centenarians are 5.1 years (=3.804/0.743) younger than age matched controls.