Figure 7.

Down regulation of mitotic histone H3 phosphorylation in wounds of AT₁R^−/− at several residues, including serine 28 as well as threonine 3 and 11. AT₂ R^−/− mice have lower expression of Phospho-Histone H3 (Thr3) in healed skin (day20) as compared to WT. The photomicrographs presented in green (Thr3 and S28) or red (Thr11) fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of Phospho-Histone H3 in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05, **p<0.005.